Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-009-0508-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Copromicroscopic Diagnosis and Prevalence of Parasitic Infections in Animals in Sitio Ibayo, San Mateo, Rizal, Philippines: Establishing a Sentinel Study for Zoonotic Disease Surveillance.
Cureus
December 2024
Department of Biology, College of Science, Polytechnic University of the Philippines, Manila, PHL.
Background: This study investigates the prevalence and intensity of parasitic infections in animal fecal samples collected from Sitio Ibayo, San Mateo, Rizal, Philippines, a suburban community considered a potential sentinel site for zoonotic disease surveillance.
Methods: Using cross-sectional sampling, 132 animal fecal samples were collected in the area exhaustively. Samples were processed through direct smear with saline solution and Lugol's iodine and flotation technique using mini- and fill-FLOTAC.
The Effect of Gender Ideal Adherence on Carer Burden and Help-Seeking in Male Carers of People With Multiple Sclerosis.
Int J MS Care
January 2025
Department of Psychology, University of Leicester, Leicester, United Kingdom.
Background: Multiple sclerosis is a chronic neurological disease that is commonly diagnosed in middle age and disproportionately affects women. Consequently, middle-aged men (as partners and husbands) are often the caregivers, a unique group in comparison with carers for people with other long-term neurological conditions, who are predominately women. Previous research has indicated that male carers respond differently from their female counterparts in terms of carer burden.
View Article and Find Full Text PDFBackground And Aims: Intestinal parasitic infection is a common disease that causes significant morbidity and mortality in developing countries, including Ethiopia. The burden of intestinal parasites is worse in schoolchildren, which leads to absenteeism from school, lower cognitive ability, affects academic performance, and causes malnutrition and anemia. While many studies have been reported, there is a paucity of published data in Debre Markos.
View Article and Find Full Text PDFPhosphorylation of Bok at Ser-8 blocks its ability to suppress IPR-mediated calcium mobilization.
Cell Commun Signal
January 2025
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Background: Bok is a poorly characterized Bcl-2 protein family member with roles yet to be clearly defined. It is clear, however, that Bok binds strongly to inositol 1,4,5-trisphosphate (IP) receptors (IPRs), which govern the mobilization of Ca from the endoplasmic reticulum, a signaling pathway required for many cellular processes. Also known is that Bok has a highly conserved phosphorylation site for cAMP-dependent protein kinase at serine-8 (Ser-8).
View Article and Find Full Text PDFOn Merit and Equity in Admission to US Physical Therapist Education Programs: A Qualitative Analysis of Faculty Habitus.
J Phys Ther Educ
December 2024
Matthew A. Nuciforo is the associate professor, chair, and program director in the Department of Physical Therapy and is the associate dean for Admissions and Enrollment in the College of Health Professions at the Rosalind Franklin University of Medicine and Science 3333 N Green Bay Rd, North Chicago, IL 60064 Please address all correspondence to Matthew A. Nuciforo.
Introduction: In contrast to the increased diversity of the US population, historically excluded racial and ethnic groups remain underrepresented in the physical therapist profession. As decision-makers, faculty exert direct influence on enrollment through evaluating applications and determining which applicants are deserving of admission to physical therapist programs.
Review Of Literature: Faculty decision-making in admissions is a cultural process which can reproduce inequities and perpetuate underrepresentation if faculty fail to recognize systemic disparities in legitimized forms of merit.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!