We present a novel ultrafast multipass laser amplifier design optimized for sub-millijoule output energy and capable of being operated at repetition rates exceeding 40 kHz. This ti:sapphire based system makes use of a grism based stretcher, a cryogenically cooled ti:sapphire crystal and an astigmatically compensated multipass amplifier design that allows for pumping with significantly lower pump pulse energies than has been demonstrated to date. We also make use of the downchirped pulse amplification scheme to minimize loss in the pulse compression process. Preliminary experiments demonstrate an output pulse energy of 290 muJ at 10 kHz and 270 muJ at 15 kHz with a pulse duration of 36 fs.
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http://dx.doi.org/10.1364/oe.14.009277 | DOI Listing |
Phys Rev Lett
December 2024
Department of Physics and Astronomy and Center for Fundamental Physics, Northwestern University, Evanston, Illinois 60208, USA.
We introduce a novel technique for enhancing the robustness of light-pulse atom interferometers against the pulse infidelities that typically limit their sensitivities. The technique uses quantum optimal control to favorably harness the multipath interference of the stray trajectories produced by imperfect atom-optics operations. We apply this method to a resonant atom interferometer and achieve thousandfold phase amplification, representing a 50-fold improvement over the performance observed without optimized control.
View Article and Find Full Text PDFClin Chem
January 2025
Department of Internal Medicine and Pediatrics, HIV Cure Research Center, Ghent University Hospital, Ghent University Ghent, Belgium.
Background: Persistent latent reservoirs of intact HIV-1 proviruses, capable of rebounding despite suppressive antiretroviral therapy (ART), hinder efforts towards an HIV-1 cure. Hence, assays specifically quantifying intact proviruses are crucial to assess the impact of curative interventions. Two recent assays have been utilized in clinical trials: intact proviral DNA assay (IPDA) and quadruplex quantitative PCR (Q4PCR).
View Article and Find Full Text PDFFront Psychiatry
December 2024
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
Introduction: This study examined the moderating effects of childhood abuse histories on the associations between low frequency (LF) and high frequency (HF) components of heart rate variability (HRV) and the development of post-traumatic stress disorder (PTSD).
Methods: Participants with physical injuries were recruited from a trauma center and followed for two years. Baseline assessments included LF, HF, and childhood abuse histories, assessed using the Nemesis Childhood Trauma Interview.
Anal Chem
December 2024
Department of Chemistry, Wuhan University, Wuhan 430072, China.
MicroRNAs (miRNAs) regulate a myriad of biological processes and thus have been regarded as useful biomarkers in biomedical research and clinical diagnosis. The specific and highly sensitive detection of miRNAs is of significant importance. Herein, a sensitive and rapid dual-amplification elemental labeling single-particle inductively coupled plasma-mass spectrometry (spICP-MS) analytical method based on strand displacement amplification (SDA) and CRISPR/Cas12a was developed for miRNA-21 detection.
View Article and Find Full Text PDFLaser Photon Rev
October 2024
Harvard Medical School, Boston, MA 02114, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Cardiology, Erasmus Medical Center, Rotterdam GD3015, The Netherlands; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Photoacoustic microscopy (PAM) is a high-resolution and non-invasive imaging modality that provides optical absorption contrast. By employing dual- or multiple-wavelength excitation, PAM extends its capabilities to offer valuable spectroscopic information. To achieve efficient multispectral PAM imaging, an essential requirement is a light source characterized by a high repetition rate and switching rate, a ≈microjoule pulse energy, and a ≈nanosecond pulse duration.
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