Purpose: To develop a grading system to evaluate the scleral spur visibility and to investigate the association between this and the angle width.
Methods: Sixty healthy normal subjects (33 with open angles and 27 with narrow angles on dark room gonioscopy) underwent anterior segment imaging with the Visante OCT (Carl Zeiss Meditec, Dublin, CA). The anterior chamber angles at 12-o' clock hour positions were imaged and analyzed. The scleral spur at each clock hour position was independently graded by 2 observers. A scleral spur visibility score (SSVS) of 2 denotes clear visibility of the scleral spur. SSVS of 0 and 1 represent undetectable and moderately by visibile scleral spur, respectively. The interobserver agreement of the SSVS was evaluated with kappa statistics. The associations between age, sex, axial length, refraction, angle width [mean anterior chamber angle detection with edge measurement and identification algorithm (ACADEMIA) angle], and the mean SSVS were examined with univariate and multivariate analyses.
Results: The mean gonioscopy grades were 3.6 and 0.8 for the open and narrow angle groups, respectively. The interobserver agreement in grading the scleral spur visibility was 0.71. The inferior angle (6:00) had the worst visibility of the scleral spur (SSVS=1.05+/-0.49) whereas the scleral spur of the nasal angle (3:00) showed the best visibility (SSVS=1.66+/-0.46). There were significant differences between SSVS at 6:00 and the other clock hours except for 5:00 and 7:00. The mean SSVS correlated positively with gonioscopy grade, anterior chamber depth, and ACADEMIA angle, and negatively with age. The only significant factor associated with scleral spur visibility was the ACADEMIA angle (P=0.013) after adjustment for other covariates.
Conclusions: The visibility of the scleral spur is an important determinant of the dimension of anterior chamber angle.
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http://dx.doi.org/10.1097/IJG.0b013e3181a98ce4 | DOI Listing |
Am J Ophthalmol
December 2024
Department of Urology, Assoc. Prof. M.D., Hitit University Erol Olçok Education and Research Hospital, Çorum, Turkey.
Purpose: To investigate the effect of tamsulosin on iris morphology, ciliary muscle thickness (CMT), pupil diameter (PD), and pupil responses to light using anterior segment optical coherence tomography and corneal topography.
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Quant Imaging Med Surg
December 2024
Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing, China.
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View Article and Find Full Text PDFFolia Biol (Praha)
December 2024
Department of Ophthalmology, Clinical College of Yizheng People's Hospital, Jiangsu Health Vocational College, Yangzhou, Jiangsu, China.
The study aimed to investigate changes in the eye axial length in juvenile guinea pigs and the expression of scleral specificity protein 1 (Sp1) and collagen type I (Col-I) under different light environments with varying spectral composition. The animals were randomly divided into five groups: natural light (N), LED light with a low colour temperature (L), E light (E), Fulia light (F), and Gulia light (G). Axial lengths were measured every two weeks, and the expression of Sp1 and Col-I in the sclera was assessed by immunohistochemistry, Western blot and RT-qPCR.
View Article and Find Full Text PDFStem Cells Dev
December 2024
Cell Therapy Service, Banc de Sang i Teixits (BST), Passeig Taulat 116, 08005, Barcelona, Spain.
In adults, the limbal stem cells (LSC) reside in the limbal region of the eye, at the junction of the cornea and the sclera where they renew the outer epithelial layer of the cornea assuring transparency. LSC deficiencies (LSCD) due to disease or injury account for one of the major causes of blindness. Among current treatments for LSCD, cornea transparency can be restored by providing new LSC to the damaged eye and induced pluripotent stem cells (iPSC) holds great promise as a new advanced cell source.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Ophtalmology, General Hospital Zadar, Ul. Bože Peričića 5, 23000 Zadar, Croatia.
Long-term use of topical prostaglandins might initiate chronic conjunctival inflammation, leading to poor outcomes of glaucoma surgery. The aim of this study was to evaluate the immunoexpression pattern of HSP70, CTGF, SNAIL, aSMA, cMYB, and HIFa in the conjunctiva, episclera, and deep sclera in patients with glaucoma undergoing deep sclerectomy in order to establish an association between staining intensities and prostaglandin F2 (PGF2) treatment. Double immunofluorescence (HSP70, CTGF, SNAIL, aSMA, cMYB, and HIFa) was performed on conjunctiva, episclera, and deep sclera samples, which were obtained from 23 patients treated with PGF2 and 8 patients without PGF2 treatment.
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