AI Article Synopsis
- Recent papers highlight the innovative use of high-throughput sequencing (HTS) for analyzing transcriptomes, showcasing its superior coverage and accuracy.
- Key findings include the discovery of new complexities in transcripts, mapping of RNA-binding protein interactions, and insights into pre-mRNA processing steps.
- The review compares HTS with traditional microarray profiling, discussing its strengths, limitations, and potential future developments in understanding RNA-level cellular networks.
Article Abstract
Recent papers have described the first application of high-throughput sequencing (HTS) technologies to the characterization of transcriptomes. These studies emphasize the tremendous power of this new technology, in terms of both profiling coverage and quantitative accuracy. Initial discoveries include the detection of substantial new transcript complexity, the elucidation of binding maps and regulatory properties of RNA-binding proteins, and new insights into the links between different steps in pre-mRNA processing. We review these findings, focusing on results from profiling mammalian transcriptomes. The strengths and limitations of HTS relative to microarray profiling are discussed. We also consider how future advances in HTS technology are likely to transform our understanding of integrated cellular networks operating at the RNA level.
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| http://dx.doi.org/10.1101/gad.1788009 | DOI Listing |
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