AI Article Synopsis
- Clinical trials for psoriasis often exclude patients with certain health conditions, making it challenging for physicians to treat those with severe psoriasis and multiple underlying issues.
- A consensus panel of 15 experts used the Delphi Method to evaluate complex psoriasis cases and generate treatment recommendations based on evidence.
- The top 10 treatment options were ranked and analyzed, offering guidance on safe and effective management strategies for difficult psoriasis cases.
Article Abstract
Clinical trials for systemic psoriasis therapy typically enroll healthy patients and exclude patients with cardiovascular disease, latent tuberculosis, liver disease, histories of malignancies, viral infections, children, and pregnant or breast-feeding women. Physicians often require guidance for optimum management of severe psoriasis in patients that have a combination of underlying disease states. To provide treatment recommendations for complex psoriasis scenarios, a consensus panel comprising 15 experts in psoriatic disease convened to review and discuss available evidence-based data and to arrive at a consensus for treatment options of difficult cases. An application of the Delphi Method was used to select case scenarios, provide medical treatment options, present the case study with existing medical evidence, and anonymously vote on treatment options. The top 10 treatment options were ranked and statistically analyzed to compare the differences between treatments. The final rankings and analysis provide guidance for practical, safe, and efficacious treatment options in a number of complex psoriasis scenarios.
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| http://dx.doi.org/10.1016/j.jaad.2009.03.017 | DOI Listing |
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