In acute experiments on rats the influence of ley-enkephalin (1 mkg/100 g) on liver bile secretion function and changes of organic contents of bile were studied. For studying the influence of opioid peptide under conditions of altered state of adreno- and cholinoreceptors, the antagonists of alpha- and beta-adrenoreceptors phentolamin (25 mkg/100 g) and obzidan (5 mkg/100 g), and the blocker of M-holinoreceptors atropine (2 mkg/100 g) were used. The pharmacological modulation of autonomous nervous systems alters the effects of ley-enkephalin on cholesecretions. Opioid peptide in the presence of antagonists of alpha-adrenoreceptors stimulates the processes of bile acids conjugation, in the presence of antagonists of beta-adrenoreceptors it cancels the effects of ley-enkephalin. The antagonists M-holinoreceptors reverse the effects of ley-enkephalin for the opposite ones: the synthesis and transport of free bile asides and cholisterine are suppressed.
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In acute experiments on rats the influence of ley-enkephalin (1 mkg/100 g) on liver bile secretion function and changes of organic contents of bile were studied. For studying the influence of opioid peptide under conditions of altered state of adreno- and cholinoreceptors, the antagonists of alpha- and beta-adrenoreceptors phentolamin (25 mkg/100 g) and obzidan (5 mkg/100 g), and the blocker of M-holinoreceptors atropine (2 mkg/100 g) were used. The pharmacological modulation of autonomous nervous systems alters the effects of ley-enkephalin on cholesecretions.
View Article and Find Full Text PDF[Catalepsy and hyperkinesis induced by the chronic administration of a tetrapeptide into the rat neostriatum].
Fiziol Zh SSSR Im I M Sechenova
January 1991
The effect of bilateral intrastriatal daily microinjection of 5 and 15 micrograms of ley-enkephalin and its synthetic analog tetrapeptide during 3 weeks on behaviour, was investigated. No obvious effect was obtained after ley-enkephalin microinjections. The tetrapeptide produced obvious cataleptic status with plastic rigidity of skeletal muscles.
View Article and Find Full Text PDFA study was made of the effect of the enkephalinase inhibitor D-phenylalanine on hematopoiesis during the immobilization stress. The long-term treatment with D-phenylalanine before the immobilization stress resulted in a significant increase of plasma ley-enkephalin in mice during the first day after exposure. Later the inhibition of bone marrow hyperplasia was recorded.
View Article and Find Full Text PDF[Interaction of the enkephalin- and dopamine-containing systems of the caudate nucleus head in realizing a conditioned food reflex in dogs].
Fiziol Zh SSSR Im I M Sechenova
February 1984
Bilateral microinjections of 15 and 45 mg of Ley-enkephalin synthetic analogue D-Ala2-D-Leu enkephalin-Arg6 into the head of caudate nuclei in dogs enhanced parameters of Pavlovian alimentary conditioned reflexes and improved the differential inhibition. Microinjection of 60 mg dopamine exerted opposite effects. The opiate antagonist naloxone (0.
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