Introduction: Patterns of stress generation in the temporomandibular joint (TMJ) after mandibular protraction with a construction bite of 5 mm advancement and 4 mm opening were investigated by using a 3-dimensional finite element method; the results were reported in Part 1. In Part 2, the effects of varying the construction bite are reported.

Methods: A 3-dimensional computer-aided design model was developed from the magnetic resonance images of a growing boy (age, 12 years), by using I-DEAS NX (version 11.0, Siemens PLM Software, Plano, Tex). Sagittal advancement was 5 mm, as in Part 1; however, the vertical openings of the construction bite were changed from 4 mm to 2 and 6 mm. The stresses thus obtained were compared for differences in magnitude and pattern.

Results: Tensile stresses migrated more posteriorly on the condylar head with increased bite height. The locations of the tensile stresses in the glenoid fossa were similar in all simulations. The TMJ as a whole showed increased loading with the increasing vertical openings.

Conclusions: This study indicates that increasing the construction bite height might give more favorable stress patterns in the TMJ, thereby improving the condylar response to functional appliances. The findings of this preliminary study need to be investigated in an animal model and in humans before deriving clinical implications.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajodo.2007.12.026DOI Listing

Publication Analysis

Top Keywords

construction bite
16
temporomandibular joint
8
mandibular protraction
8
3-dimensional finite
8
finite element
8
tensile stresses
8
bite height
8
bite
5
stress distribution
4
distribution temporomandibular
4

Similar Publications

Objective: To study the biomechanical changes induced by differences in perioral force in patients with missing anterior maxillary teeth at rest via finite element analysis (FEA).

Methods: Using conical beam CT (CBCT) images of a healthy person, models of the complete maxillary anterior dental region (Model A) and maxillary anterior dental region with a missing left maxillary central incisor (Model B) were constructed. The labial and palatine alveolar bone and tooth surface of the bilateral incisor and cusp regions were selected as the application sites, the resting perioral force was applied perpendicular to the tissue surface, and the changes in maxillary stress and displacement after the perioral force was simulated were analyzed.

View Article and Find Full Text PDF

In the course of pipe jacking construction, the carrying-soil effect frequently arises, influenced by factors such as excavation unloading, ongoing disturbance from successive pipe sections, and the progressive accumulation of soil adhesion. The pipe jacking slurry serves as a critical agent for friction reduction and strata support, essential for the secure advancement of the construction process. This study introduces the Microbial-Induced Calcium Carbonate Precipitation (MICP) technology into the realm of pipe jacking slurry, aiming to enhance its friction-reduction capabilities and the stability of the soil enveloping the pipe.

View Article and Find Full Text PDF

Production of Hyaluronidase by .

J Fungi (Basel)

December 2024

Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Hyaluronidases have been a subject of great interest in medical and cosmeceutical applications. Previously, our group demonstrated that the venom glands of contain hyaluronidase enzymes (VesT2s), and heterologous expression of the corresponding gene () in systems results in inclusion bodies, necessitating functional folding using urea. Here, we report the successful heterologous expression of VesT2a in the expression system, with gene construction achieved using Golden.

View Article and Find Full Text PDF
Article Synopsis
  • Capnocytophaga spp. are zoonotic pathogens from the mouths of dogs and cats that can cause serious infections in humans through bites and scratches, highlighting the need for effective antimicrobial treatment due to their rapid symptom onset.
  • Resistance and susceptibility to nine antibiotics were tested on 57 isolates from different species of Capnocytophaga using E-test methods, revealing high minimum inhibitory concentrations (MICs) for several antibiotics, while imipenem and amoxicillin/clavulanic acid had low MICs across the board.
  • The study identified both known resistance genes and a novel resistance gene (CST-1), which can inactivate penicillin and certain cephalosporins, underscoring the importance of understanding antimicrobial resistance in treating
View Article and Find Full Text PDF
Article Synopsis
  • Glioblastoma multiforme (GBM) presents a challenge for treatment due to its antigenic variability, prompting researchers to develop multivalent immunotherapies that target multiple tumor antigens to improve effectiveness.
  • The study introduces a new class of antibodies called DNA-encoded tri-specific T-cell engagers (DTriTEs) that target two specific GBM antigens and engage T cells, showing promising in vitro and in vivo results.
  • The leading DTriTE construct, DT2035, not only significantly reduced tumor burden and improved survival rates in mouse models but also showed sustained expression and induced strong immune responses, making it a potential game-changer for GBM treatment.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!