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Without visual feedback voluntary torque is overestimated during muscle potentiation despite similar motor unit firing rate and perception of exertion.
J Neurophysiol
January 2025
School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, ON, Canada.
The purpose was to assess whether visual feedback of torque contributes to motor unit (MU) firing rate reduction observed during post-activation potentiation (PAP) of skeletal muscle. From 15 participants 23 MUs were recorded with intramuscular fine-wire electrodes from the tibialis anterior during isometric dorsiflexion contractions at 20% of maximum, with and without both PAP and visual feedback of torque. A 5s maximal voluntary contraction (MVC) was used to induce PAP, and evoked twitch responses were assessed before and after.
View Article and Find Full Text PDFHealthcare waste management knowledge, attitudes and practices of laboratory workers at a regional hospital, Lesotho.
Afr J Lab Med
December 2024
Department of Environmental Health, Faculty of Health Sciences, National University of Lesotho, Roma, Maseru, Lesotho.
Background: Safe management of healthcare waste (HW) safeguards laboratory biosafety and biosecurity. Knowledge and attitudes influence HW practices, presenting a need for evidence of the current status.
Objective: This study assessed the knowledge, attitudes and practice of laboratory workers towards waste management at a regional hospital laboratory in Lesotho.
Building Narratives of Effectiveness and Customer Orientation at the Interface of Different Actors in the Lifestyle Guidance Service Process.
J Patient Exp
January 2025
Department of Administrative Sciences, University of Lapland, Rovaniemi, Finland.
Co-production is expected to lead to more efficient and effective services. In response, this study aims to describe and understand the construction of effectiveness and the manifestation of customer orientation among the actors involved in the service process of lifestyle guidance. A qualitative narrative study was designed, and data were collected through the thematic interviews (n = 9) with the management, employees and customers of a Finnish public healthcare and social welfare organisation.
View Article and Find Full Text PDFControl of metalloenzyme activity using photopharmacophores.
Coord Chem Rev
January 2024
Department of Chemistry, University of Texas at Austin, 105 E 24th St, Austin, TX 78712, United States.
Metalloenzymes are responsible for numerous physiological and pathological processes in living organisms; however, there are very few FDA-approved metalloenzyme-targeting therapeutics (only ~ 67 FDA-approved metalloenzyme inhibitors as of 2020, less than ~ 5 % of all FDA-approved therapeutics). Most metalloenzyme inhibitors have been developed to target the catalytic metal centers in metalloenzymes the incorporation of metal-binding groups. Light-controlled inhibition of metalloenzymes has been used as a means to specifically activate and inactivate inhibitor engagement at a desired location and time light irradiation, allowing for precise spatiotemporal control over metalloenzyme activity.
View Article and Find Full Text PDFImplementing a Responsible Conduct of Research Curriculum for an Undergraduate Summer Clinical Research Program in Quantitative Sciences.
J Med Educ Curric Dev
January 2025
Department of Health Policy and Management, Columbia University Mailman School of Public Health, New York, NY, USA.
Objectives: Instilling the principles of ethical and responsible medical research is critical for educating the next generation of clinical researchers. We developed a responsible conduct of research (RCR) workshop and associated curriculum for undergraduate trainees in a quantitative clinical research program.
Methods: Topics in this 7-module RCR workshop are relevant to undergraduate trainees in quantitative fields, many of whom are learning about these concepts for the first time.
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