Unlike the preparation of other purine nucleosides, transglycosylation from a pyrimidine nucleoside and guanine is difficult because of the low solubility of this base. Thus, another strategy, based on the coupled action of two whole cell biocatalyzed reactions, transglycosylation and deamination, was used. Enterobacter gergoviae and Arthrobacter oxydans were employed to synthesize 9-beta-d-arabinofuranosylguanine (AraG), an efficient anti leukemic drug.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2009.05.106 | DOI Listing |
Publication Analysis
Top Keywords
synthesis 9-beta-d-arabinofuranosylguanine
4
9-beta-d-arabinofuranosylguanine combined
4
combined cell
4
cell biocatalysts
4
biocatalysts preparation
4
preparation purine
4
purine nucleosides
4
nucleosides transglycosylation
4
transglycosylation pyrimidine
4
pyrimidine nucleoside
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!