Neuroimaging of schizophrenia: what it reveals about the disease and what it tells us about a patient.

Ann Acad Med Singap

Deparment of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, Camberwell, De Crespigny Park, London, United Kingdom.

Published: May 2009

Neuroimaging in psychiatry, and in schizophrenia in particular, moves ahead at a rapid pace delivering new insights into the nature of the illness and its intriguing symptoms via technologies such as MRI, fMRI, PET, and SPET scanning. How do these impact on understanding the patient in front of us? What do they mean for the busy clinician in clinic? We outline some of the recent findings in neuroimaging research of schizophrenia and consider their potential application in clinical practice.

Download full-text PDF

Source

Publication Analysis

Top Keywords

neuroimaging schizophrenia
8
schizophrenia reveals
4
reveals disease
4
disease tells
4
tells patient
4
patient neuroimaging
4
neuroimaging psychiatry
4
psychiatry schizophrenia
4
schizophrenia moves
4
moves ahead
4

Similar Publications

Driving brain state transitions via Adaptive Local Energy Control Model.

Neuroimage

January 2025

College of Computer Science and Technology (College of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China. Electronic address:

The brain, as a complex system, achieves state transitions through interactions among its regions and also performs various functions. An in-depth exploration of brain state transitions is crucial for revealing functional changes in both health and pathological states and realizing precise brain function intervention. Network control theory offers a novel framework for investigating the dynamic characteristics of brain state transitions.

View Article and Find Full Text PDF

Left posterior superior temporal gyrus and its structural connectivity in schizophrenia.

Psychiatry Res Neuroimaging

January 2025

Department of Psychiatry, Kyoto University Graduate School of Medicine, Address: 54 Shogoin-kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

The left posterior superior temporal gyrus (pSTG) is thought to be involved in the pathophysiology and core symptoms of schizophrenia, although its structural connectivity has not yet been systematically investigated. Here, we aimed to evaluate its white matter (WM) connectivity with Broca's area, the thalamus, and the right pSTG. Eighty-three patients with schizophrenia and 141 healthy controls underwent diffusion-weighted imaging and T1-weighted three-dimensional magnetic resonance imaging.

View Article and Find Full Text PDF

Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes. Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functional anomalies in frontoparietal brain regions. To date, limited studies have investigated the association between regional cerebral blood flow (CBF) and impaired insight in schizophrenia.

View Article and Find Full Text PDF

Background And Hypothesis: Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a central role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences.

View Article and Find Full Text PDF

Adolescent-onset schizophrenia (AOS) is relatively rare, under-studied, and associated with more severe cognitive impairments and poorer outcomes than adult-onset schizophrenia. Neuroimaging has shown altered regional activations (first-order effects) and functional connectivity (second-order effects) in AOS compared to controls. The pairwise maximum entropy model (MEM) integrates first- and second-order factors into a single quantity called energy, which is inversely related to probability of occurrence of brain activity patterns.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!