Lung cancer metastatic to the masticator space.

Background: Distant metastasis from lung cancer occurs most frequently to the brain, bone, adrenal gland, liver, lymph nodes, and spinal cord. However, masticator space metastasis is rarely found among lung cancer patients.

Case Report: We report a case of large cell neuroendocrine carcinoma of the lung with metastasis to the masticator space diagnosed by imaging and histopathological examinations.

Conclusion: The present case highlights the fact that large cell neuroendocrine carcinoma of the lung can result in an uncommon isolated masticator space metastasis. Clinicians should carefully evaluate cancer patients who report a painful sensation in the cheek. Thorough dental and physical examination, and imaging studies could provide early diagnosis and treatment.