Background And Objective: The objective of this study was to assess the exposure to environmental tobacco smoke (ETS) by means of the concentration of salivary cotinine in a sample of adolescent students, and its relationship with active and passive tobacco consumption.
Methods: A cross-sectional survey was conducted in 92 secondary education and high school pupils (16-20 years). Salivary samples were collected and salivary cotinine was measured by gas chromatography/mass spectrometry. Salivary cotinine medians and interquartile ranges were calculated. Significant statistical differences were detected with the non parametric test for medians.
Results: The median of salivary cotinine concentration in current smokers was 91.5 ng/ml (RI: 62.4-125); in former smokers 7.9 ng/ml (RI: 5.1-15.5) and in never smokers 1.9 ng/ml (RI: 0-3.6). In smokers of more than 10 cigarettes per day, the result was 98.3 ng/ml (RI:63.4-142.9). Among non-smokers (never-smoker and ex-smokers), the median of salivary cotinine in non-smokers living with smokers was 3.3 ng/ml (RI: 0-8.6) versus 2.9 ng/ml (RI: 1.1-6.9) in those living with non-smokers.
Conclusions: The salivary cotinine concentration increases with the intensity of tobacco consumption and the perception of passive exposure to tobacco smoke.
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http://dx.doi.org/10.1016/j.medcli.2009.03.022 | DOI Listing |
BMJ Open
January 2025
Hospital Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA
Introduction: Hospitalisation represents an opportunity to identify and treat e-cigarette use among adolescents and young adults (AYAs). Knowledge on how to provide this care is lacking. We aim to fill this gap by developing an e-cigarette use intervention and evaluating preliminary efficacy and implementation outcomes among hospitalised AYAs.
View Article and Find Full Text PDFClin Exp Dent Res
December 2024
Laboratory of Clinical, Forensic, Industrial and Environmental Toxicology, University Hospital of Liège, Liège, Belgium.
Objectives: Smoking is considered a major risk factor for periodontitis genesis and progression. In clinical studies, specific indicators have been used to characterize the smoking status of the patient as the number of cigarettes consumed (NCC), the pack-years (PY), or Fagerström Test for Nicotine Dependence (FTND). However, available literature is missing on the relationship between cotinine gingival intoxication and smoking indicators.
View Article and Find Full Text PDFbioRxiv
November 2024
Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Saliva is a widely used sample in epigenetic research with children due to its non-invasive nature. Since DNA methylation (DNAm) profile is cell type (CT) specific, salivary DNAm associations with exposures may be influenced by CT compositions, which is highly variable in saliva as it contains immune and buccal epithelial cells (BEC). Reference-based CT deconvolution and statistically adjusting estimated CT in DNAm analyses have become an increasingly common practice.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Instituto de Ciência e Tecnologia, Universidade Estadual Paulista (UNESP), Câmpus São José dos Campos, Av. Eng. Francisco José Longo, 777, São Dimas, São José dos Campos 12245-000, São Paulo, Brazil.
In recent years, the use of electronic cigarettes (e-cigs) has increased. However, their long-term effects on oral health and saliva remain poorly understood. Therefore, this study aimed to evaluate the saliva of e-cig users and investigate possible biomarkers.
View Article and Find Full Text PDF3D Print Med
October 2024
Department of Psychological Science, Creighton University, Omaha, NE, USA.
Background: Smoking in pregnancy continues to cause significant morbidity to mothers and babies and contributes to tremendous costs to society. Maternal-fetal attachment (MFA) may differentiate smokers who quit or pregnant smokers from non-smokers. Researchers have recommended utilizing interventions that improve MFA to help decrease smoking within pregnancy.
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