The patients who underwent reconstruction of cleft lip and palate had clinically abnormal characteristics such as cicatricial contracture in the cleft area, narrow arches, missing teeth, and fistula. Most of those patients showed severe class III malocclusion with underdevelopment of the maxillary complex. In such patients, the treatment objectives in orthodontics were mainly anterior and lateral expansions of the maxillary arches, and inhibition of mandibular growth. In recent years, the maxillary protractor has been used positively in the treatment of the underdeveloped maxillary complex. In this study, we report on two patients with cleft lip and palate, and underdevelopment of the maxillary complex. Maxillary protractors were used beneficially at the period of the dento-craniofacial growth spurt. In these two cases, improvement of disharmony was obtained in the antero-posterior relationship between the maxilla and the mandible. The effects of the treatment were forward movement of the maxilla and growth inhibition of the mandible. Accordingly, the use of the maxillary protractor for cleft lip and palate patients with underdeveloped maxilla at the period of the dento-craniofacial growth spurt was shown to be important.
Download full-text PDF |
Source |
---|
Med Oral Patol Oral Cir Bucal
January 2025
Bezmialem Vakif University Faculty of Dentistry Department of Oral and Maxillofacial Surgery Fatih, Istanbul, Turkey
Background: The study aimed to investigate the effect of customized lateral nasal wall osteotomy (LNO) on the lateral nasal wall (LNW) and pterygomaxillary junction (PMJ) separation during Le Fort I. We hypothesized that customized LNO on the LNW affect the PMJ separation type.
Material And Methods: This prospective, controlled, randomized study included forty-three patients were randomly assigned to either the conventional or customized (study) osteotomy groups.
Cell Death Discov
January 2025
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective treatment currently exists. Our previous studies demonstrated that mutations associated with AEC syndrome lead to p63 protein misfolding and aggregation, exerting a dominant-negative effect.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Oral and Maxillofacial Surgery, University Hospital of Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
: Defects in maxillary and mandibular continuity are common in maxillofacial practice. They can occur after trauma, osteonecrosis, congenital jaw deformities, or surgical resection of benign or malignant tumours. Reconstruction with microvascular bone flaps and subsequent prosthetic rehabilitation is considered the contemporary first line treatment.
View Article and Find Full Text PDFJ Craniomaxillofac Surg
December 2024
Department of Medical Genetics and Genomic Medicine, University of Campinas (UNICAMP), SP, Brazil. Electronic address:
This study describes the results of whole exome sequencing in the etiological investigation and genetic counseling of families presenting with non-syndromic oral clefts with vertical transmission recorded in the Brazilian Database on Craniofacial Anomalies. Whole exome sequencing was performed in 18 families presenting with non-syndromic oral clefts with vertical transmission, and variant filtering was used to identify rare, and also possibly pathogenic variants in genes associated with oral clefts. Overall, our study identified seven families (38.
View Article and Find Full Text PDFCongenit Anom (Kyoto)
January 2025
Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
Pregnancy loss is a significant concern worldwide, encompassing miscarriage and stillbirth. Miscarriage, defined as the loss of a baby before 28 weeks of gestation, accounts for approximately 15% of pregnancies. Stillbirth, occurring at or after 28 weeks of gestation, affects nearly 2.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!