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A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut.
Cell Rep
March 2025
School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, UK; School of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. Electronic address:
Multipotent adult stem cells balance self-renewal with differentiation into various cell types. How this balance is regulated at the transcriptional level is poorly understood. Here, we show that a network of basic helix-loop-helix (bHLH) transcription factors controls both stemness and bipotential differentiation in the Drosophila adult intestine.
View Article and Find Full Text PDFMechanically Robust Mesoporous UiO-66-NH/Nanofibrous Aerogel for Organophosphonates Detoxification.
Adv Sci (Weinh)
March 2025
Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC, 27695, USA.
There is a critical need for novel composite materials for high-performance chemical filtration and detoxification of organophosphonates (OPs) and other harmful compounds found in nerve agents, pesticides, and industrial processes. In this work, rapid hydrolysis of OPs using high-surface-area zirconium-based MOF-aerogel composites is demonstrated. Using a unique surfactant-templated solvothermal synthesis method, mesoporous UiO-66-NH grown on the fibers within a polyacrylonitrile (PAN)/polyvinylpyrrolidone (PVP) nanofibrous sponge can produce a 3D MOF-polymer matrix with a specific surface area of up to 900 m g -almost 2X larger than the highest previously reported values while maintaining robust mechanical integrity.
View Article and Find Full Text PDFEpigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of "cellular and molecular biology of the heart" and "cardiac rehabilitation and cardiovascular prevention" of the Italian Society of Cardiology (SIC).
Int J Cardiol
March 2025
Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Fisciano, Italy. Electronic address:
The benefits of cardiac rehabilitation (CR) have been demonstrated in patients after myocardial infarction (MI), and in patients with chronic heart failure (HF). The core components of the CR program include improvement in exercise tolerance and optimization of coronary risk factors (i.e.
View Article and Find Full Text PDFMicro-gyms as a catalyst for healthy aging in university and healthcare settings: applications for the Semmelweis-EUniWell Workplace Health Promotion Model Program.
Geroscience
March 2025
Healthy Aging Section, European Public Health Association, Utrecht, The Netherlands.
Europe is experiencing a significant demographic shift, with aging populations posing economic and social challenges due to increased healthcare costs and a higher prevalence of age-related diseases. Hungary, in particular, faces these challenges acutely due to higher morbidity and mortality rates from a range of chronic age-related diseases and behavioral risk factors. Addressing these issues requires innovative approaches to promote healthy aging.
View Article and Find Full Text PDFWhile sex education has been linked to adolescent health, few studies have examined how comprehensiveness of school-based sex education may promote young adult sexual wellbeing. The current study used latent class analysis to examine patterns in the comprehensiveness of topics included in sex education among a national sample of young adults ( = 676). Many participants had not received sex education (40%) or had received sex education that was focused on abstinence (20%) or sexual risks (25%).
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