AI Article Synopsis
- Plasmon-resonant gold nanorods are used as contrast agents in optical coherence tomography (OCT), focusing on their low backscattering albedo to enhance detection sensitivity.
- A key concept, backscattering albedo (a'), helps differentiate the contrast agents from surrounding tissue, allowing for more precise imaging.
- The study shows that these gold nanorods can be effectively detected at concentrations as low as 30 ppm, demonstrating their potential to improve OCT contrast beyond what extinction measurements alone could achieve.
Article Abstract
Plasmon-resonant gold nanorods are demonstrated as low backscattering albedo contrast agents for optical coherence tomography (OCT). We define the backscattering albedo, a', as the ratio of the backscattering to extinction coefficient. Contrast agents which modify a' within the host tissue phantoms are detected with greater sensitivity by the differential OCT measurement of both a' and extinction. Optimum sensitivity is achieved by maximizing the difference between contrast agents and tissue, |a'(ca) - a'(tiss)|. Low backscattering albedo gold nanorods (14x 44 nm; lambda(max) = 780 nm) within a high backscattering albedo tissue phantom with an uncertainty in concentration of 20% (randomized 2+/-0.4% intralipid) were readily detected at 82 ppm (by weight) in a regime where extinction alone could not discriminate nanorods. The estimated threshold of detection was 30 ppm.
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| http://dx.doi.org/10.1364/oe.14.006724 | DOI Listing |
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