The image resolution and contrast in Near-Infrared (NIR) tomographic image reconstruction are affected by parameters such as the number of boundary measurements, the mesh resolution in the forward calculation and the reconstruction basis. Increasing the number of measurements tends to make the sensitivity of the domain more uniform reducing the hypersensitivity at the boundary. Using singular-value decomposition (SVD) and reconstructed images, it is shown that the numbers of 16 or 24 fibers are sufficient for imaging the 2D circular domain for the case of 1% noise in the data. The number of useful singular values increases as the logarithm of the number of measurements. For this 2D reconstruction problem, given a computational limit of 10 sec per iteration, leads to choice of forward mesh with 1785 nodes and reconstruction basis of 30x30 elements. In a three-dimensional (3D) NIR imaging problem, using a single plane of data can provide useful images if the anomaly to be reconstructed is within the measurement plane. However, if the location of the anomaly is not known, 3D data collection strategies are very important. Further the quantitative accuracy of the reconstructed anomaly increased approximately from 15% to 89% as the anomaly is moved from the centre to boundary, respectively. The data supports the exclusion of out of plane measurements may be valid for 3D NIR imaging.
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http://dx.doi.org/10.1364/oe.14.006113 | DOI Listing |
Ann Thorac Surg Short Rep
December 2024
Division of Cardiac Surgery, Inova Heart and Vascular Institute, Inova Health Systems, Falls Church, Virginia.
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View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Innate immunity relies on Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns. The TIR (Toll/interleukin-1 receptor) domain-containing TLR adaptors TRIF (TIR domain-containing adaptor-inducing interferon-β) and TRAM (TRIF-related adaptor molecule) are essential for MyD88-independent TLR signaling. However, the structural basis of TRIF and TRAM TIR domain-based signaling remains unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Memory & Aging Center, Department of Neurology, University of California in San Francisco, San Francisco, CA, USA
Background: Neuropathological studies indicate that locus coeruleus(LC) volume decreases in Alzheimer’s disease(AD) by 8% at each stage, (from Braak 0‐1), whereas in normal aging, the LC remains unchanged. These changes make LC volumetry by neuroimaging a promising way to track AD progression even before symptoms appear. However, LC’s small size and location make it prone to imaging artifacts.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Memory & Aging Center, Department of Neurology, University of California in San Francisco, San Francisco, CA, USA
Background: Neuropathological studies indicate that locus coeruleus(LC) volume decreases in Alzheimer’s disease(AD) by 8% at each stage, (from Braak 0‐1), whereas in normal aging, the LC remains unchanged. These changes make LC volumetry by neuroimaging a promising way to track AD progression even before symptoms appear. However, LC’s small size and location make it prone to imaging artifacts.
View Article and Find Full Text PDFJTCVS Open
December 2024
Department of Cardiothoracic Surgery, Friedrich-Schiller-University Jena, Jena, Germany.
Objectives: There is an ongoing debate whether percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is the better choice for treatment of left main (LM) stenosis. We aimed to provide external validation for the recently reviewed guideline recommendations for invasive LM therapy by evaluating the impact of CABG or PCI on long-term survival from local reports of different regions in the world. We performed a systematic review and meta-analysis to address contemporary registry studies comparing PCI and CABG for patients with LM stenosis.
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