Appropriately substituted nonracemic allyl alcohols, readily prepared from the corresponding enones by application of the CBS methodology, were converted to optically active cycloheptenone derivatives with almost complete transfer of chirality via an efficient "one-pot", cycloisomerization/Claisen rearrangement process. This methodology was directly applied to the expedient total synthesis of (-)-frondosin B.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711515PMC
http://dx.doi.org/10.1021/ol900967jDOI Listing

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