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Unraveling the hormonal approaches for the treatment of rheumatoid arthritis and its complementary interventions.
Inflammopharmacology
January 2025
Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, India.
Rheumatoid Arthritis (RA) is an autoimmune, chronic, systemic inflammatory disease that causes redness, swelling, stiffness, and joint pain. It is a long-lasting disease that can have a widespread impact on the body, often affecting the hands, feet, and wrists. The immune cells, such as dendritic cells, T cells, B cells, macrophages, and neutrophils, play a significant role in bone degradation and inflammation.
View Article and Find Full Text PDFBone Disease Associated with Inactivating Aromatase Mutations and its Management.
Calcif Tissue Int
January 2025
Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Santa Maria Alle Scotte, Siena, Italy.
Aromatase deficiency (ORPHA:91; OMIM: 613,546) is a rare, autosomal recessive disorder due to loss of function mutations in the CYP19A1 gene, described in both genders with an estimated incidence below 1/1000000. While in female the clinical manifestations generally occur at birth or in early infancy, and mainly involve sexual characteristics, in men clinical signs of aromatase deficiency mostly occur in puberty and especially in late puberty, so that diagnosis is generally established after the second decade due to tall stature, unfused epiphyses and reduced bone mass. Here we review the available information concerning the skeletal and extraskeletal phenotype and the clinical management of bone health in patients with aromatase CYP19A1 gene mutations.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Background: Endogenous estrogen history across the life course may be associated with better cognitive maintenance. Few large longitudinal studies have evaluated this prospectively, and results have been inconsistent. We assessed the association of reproductive span, an indicator of endogenous estrogen history, with cognitive change in older women.
View Article and Find Full Text PDFBackground: More than 2/3 of Alzheimer's Disease (AD) patients are women, which has led to increased interest in the neurophysiological impact of estrogen decline during menopause. While early evidence suggested that hormone replacement therapy (HRT) may be protective against dementia, more recent studies have found inconclusive or even harmful effects.
Method: We tested the association between HRT use (estrogen or estrogen + progestin) and AD-related neuropathological outcomes measured on autopsy data in females from the National Alzheimer's Coordinating Center (NACC) (N = 3423).
Clinical Manifestations.
Alzheimers Dement
December 2024
Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Background: Studies have reported the neuroprotective role of estrogen, and that the post-menopausal state could be a risk factor for cognitive decline. However, the relationship between menopausal age and cognitive functions has not been adequately studied in the Indian population.
Method: Srinivaspura Neuro Senescence and Cognition (SANSCOG) is an ongoing rural community-based longitudinal study on aging in India.
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