AI Article Synopsis
- The study investigated how different environmental factors affect the emission of ethylene oxide (EO) from sterilized syringes, with a goal of reducing worker exposure.
- The controlled experiments showed that temperature, relative humidity, and air change rate significantly influenced EO emissions, with complex interactions among these variables.
- Effective control measures, particularly through adjusting air change rates, can help manage EO emissions, but proper ventilation systems must be implemented for safety.
Article Abstract
Objectives: This study examined the emission characteristics of ethylene oxide (EO)-sterilized syringes under various environmental conditions, aiming to develop control strategies to minimize worker exposure.
Methods: Experiments were performed in a facility in which temperature, relative humidity (RH), and air change rate (ACR) were controlled.
Results: Analytical results indicate that the main effects of the four test variables on kinetic parameters were statistically significant (p < 0.05), except for the effect of the product on the decay rate constant, the effect of ACR on maximum EO concentration, and effect of RH on the area under the curve-days 1 and 2. The interactive effects among test variables were also evident, indicating complex emission behaviors. The mean EO emission factors during the days 1 and 2 and at the 48th hour for the 1- and 30-ml products were 2302, 1301, and 1031 mg/m(3)/h, and 871, 490, and 381 mg/m(3)/h, respectively. The times required for air EO concentrations from tested products to return to approximately 0 and 1 ppm (permissible limit) were 417 and 218 h, respectively.
Conclusions: Plastic content, temperature, RH, and ACR affected EO emissions. ACR is an achievable means of control; however, the aeration area/system should be isolated to ensure adequate ventilation is achieved.
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| http://dx.doi.org/10.1002/jbm.b.31432 | DOI Listing |
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