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Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy.
Sci Rep
December 2024
Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Warfarin is the most widely used oral anticoagulant in clinical practice. The cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) genotypes are associated with warfarin dose requirements in China. Accurate genotyping is vital for obtaining reliable genotype-guided warfarin dosing information.
View Article and Find Full Text PDFIdentifying DNA methylation sites affecting drug response using electronic health record-derived GWAS summary statistics.
Pac Symp Biocomput
December 2024
Department of Biochemistry, Stanford University Medical School Stanford, CA 94305, USA,
Adverse drug responses (ADRs) result in over 7,000 deaths annually. Pharmacogenomic studies have shown that many ADRs are partially attributable to genetics. However, emerging data suggest that epigenetic mechanisms, such as DNA methylation (DNAm) also contribute to this variance.
View Article and Find Full Text PDFCharacterizing the genetic architecture of drug response using gene-context interaction methods.
Cell Genom
December 2024
Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:
Identifying factors that affect treatment response is a central objective of clinical research, yet the role of common genetic variation remains largely unknown. Here, we develop a framework to study the genetic architecture of response to commonly prescribed drugs in large biobanks. We quantify treatment response heritability for statins, metformin, warfarin, and methotrexate in the UK Biobank.
View Article and Find Full Text PDFClinical Application of Pharmacogenomics in the Administration of Common Cardiovascular Medications.
Curr Rev Clin Exp Pharmacol
December 2024
Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Introduction: Genomic variations among individuals can greatly affect their responses to different medications. Pharmacogenomics is the area of study that aims to understand the relationship between these various genetic variations and subsequent drug responses. Many medications used to optimize cardiovascular health are affected by these genetic variants and these relationships can subsequently impact dosing strategies in patients.
View Article and Find Full Text PDFPharmacogenomics in Sri Lanka: a comprehensive systematic review of the research landscape and clinical implications.
Pharmacogenomics
November 2024
Department of Anatomy, Genetics & Biomedical Informatics, Faculty of Medicine, University of Colombo, Sri Lanka.
Article Synopsis
- Pharmacogenomics is gaining traction in South Asia, particularly in Sri Lanka, aiming to enhance drug therapies and minimize side effects for patients.
- A comprehensive review analyzed research in Sri Lanka, where studies were classified into categories like clinical correlational, descriptive, and novel assay development; 11 articles and 8 theses were reviewed.
- While progress has been made, additional clinical studies and a wider scope of genomic research are necessary, alongside efforts to address challenges like funding and public awareness, to successfully implement personalized medicine in the region.
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