The existence of visual hallucinations with prominent temporal oscillations is well documented in conditions such as Charles Bonnett Syndrome. To explore these phenomena, a continuum model of cortical activity that includes additional physiological features of axonal propagation and synapto-dendritic time constants, is used to study the generation of hallucinations featuring both temporal and spatial oscillations. A detailed comparison of the physiological features of this model with those of two others used previously in the modeling of hallucinations is made, and differences, particularly regarding temporal dynamics, relevant to pattern formation are analyzed. Linear analysis and numerical calculation are then employed to examine the pattern forming behavior of this new model for two different forms of spatiotemporal coupling between neurons. Numerical calculations reveal an oscillating mode whose frequency depends on synaptic, dendritic, and axonal time constants not previously simultaneously included in such analyses. Its properties are qualitatively consistent with descriptions of a number of physiological disorders and conditions with temporal dynamics, but the analysis implies that corticothalamic effects will need to be incorporated to treat the consequences quantitatively.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00422-009-0315-8DOI Listing

Publication Analysis

Top Keywords

pattern formation
8
physiological features
8
time constants
8
temporal dynamics
8
spatiotemporal dynamics
4
dynamics pattern
4
formation primary
4
primary visual
4
visual cortex
4
hallucinations
4

Similar Publications

Silica Nanoparticle-Protein Aggregation and Protein Corona Formation Investigated with Scattering Techniques.

ACS Appl Mater Interfaces

January 2025

School of Science, STEM College, RMIT University, 124 La Trobe Street, Melbourne, Victoria 3000, Australia.

Protein-nanoparticle interactions and the resulting corona formation play crucial roles in the behavior and functionality of nanoparticles in biological environments. In this study, we present a comprehensive analysis of protein corona formation with superfolder green fluorescent protein (sfGFP) and bovine serum albumin in silica nanoparticle dispersions using small-angle X-ray scattering (SAXS) and dynamic light scattering (DLS). For the first time, we subtracted the scattering of individual proteins in solution and individual nanoparticles from the protein-nanoparticle complexes.

View Article and Find Full Text PDF

Blood-based epigenome-wide association study and prediction of alcohol consumption.

Clin Epigenetics

January 2025

Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used to derive a more objective measure of alcohol consumption by incorporating information from cytosine-phosphate-guanine (CpG) sites known to be linked to the trait.

View Article and Find Full Text PDF

Background: During mammalian spermatogenesis, the cytoskeleton system plays a significant role in morphological changes. Male infertility such as non-obstructive azoospermia (NOA) might be explained by studies of the cytoskeletal system during spermatogenesis.

Methods: The cytoskeleton, scaffold, and actin-binding genes were analyzed by microarray and bioinformatics (771 spermatogenic cellsgenes and 774 Sertoli cell genes).

View Article and Find Full Text PDF

Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max).

BMC Genomics

January 2025

Henan Collaborative Innovation Center of Modern Biological Breeding, College of Agronomy, Henan Institute of Science and Technology, Xinxiang, 453003, China.

Background: The Sec14 domain is an ancient lipid-binding domain that evolved from yeast Sec14p and performs complex lipid-mediated regulatory functions in subcellular organelles and intracellular traffic. The Sec14 family is characterized by a highly conserved Sec14 domain, and is ubiquitously expressed in all eukaryotic cells and has diverse functions. However, the number and characteristics of Sec14 homologous genes in soybean, as well as their potential roles, remain understudied.

View Article and Find Full Text PDF

Background: Developing interventions along with the population of interest using systems thinking is a promising method to address the underlying system dynamics of overweight. The purpose of this study is twofold: to gain insight into the perspectives of adolescents regarding: (1) the system dynamics of energy balance-related behaviours (EBRBs) (physical activity, screen use, sleep behaviour and dietary behaviour); and (2) underlying mechanisms and overarching drivers of unhealthy EBRBs.

Methods: We conducted Participatory Action Research (PAR) to map the system dynamics of EBRBs together with adolescents aged 10-14 years old living in a lower socioeconomic, ethnically diverse neighbourhood in Amsterdam East, the Netherlands.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!