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Enzymes as green and sustainable tools for DNA data storage.
Chem Commun (Camb)
January 2025
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
DNA is considered as an ideal supramolecular material for information storage with high storage density and long-term stability. Enzymes, as green and sustainable tools, offer several unique advantages for DNA-based information storage. These advantages include low cost and reduced generation of hazardous wastes during DNA synthesis, as well as the improvements in data reading speed and data recovery accuracy.
View Article and Find Full Text PDFThe use of Artificial Intelligence Algorithms in drug development and clinical trials: A scoping review.
Int J Med Inform
January 2025
Universidade Federal de São Paulo (UNIFESP), professor afiliado do Departamento de Informática em Saúde da Escola Paulista de Medicina (EPM/UNIFESP), Brazil. Electronic address:
Background: Artificial Intelligence (AI) is transforming drug development and clinical trials, helping researchers find new treatments faster and personalize care for patients. By automating tasks like molecule screening and predicting treatment outcomes, AI addresses critical challenges in modern medicine.
Objectives: This review explores how AI is being used in drug development and clinical trials, focusing on its benefits, limitations, and potential to improve healthcare outcomes.
Current approaches in CRISPR-Cas systems for diabetes.
Prog Mol Biol Transl Sci
January 2025
R and D, Salem Microbes Private Limited, Salem, Tamil Nadu, India. Electronic address:
In the face of advancements in health care and a shift towards healthy lifestyle, diabetes mellitus (DM) still presents as a global health challenge. This chapter explores recent advancements in the areas of genetic and molecular underpinnings of DM, addressing the revolutionary potential of CRISPR-based genome editing technologies. We delve into the multifaceted relationship between genes and molecular pathways contributing to both type1 and type 2 diabetes.
View Article and Find Full Text PDFInternational Symposium on Ruminant Physiology: The involvement of the endocannabinoid system in metabolic and inflammatory responses in dairy cows during negative energy balance.
J Dairy Sci
January 2025
Department of Ruminant Science, Institute of Animal Sciences, ARO Volcani Institute, Israel; Department of Animal Science, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
The endocannabinoid system (ECS) is involved in the regulation of energy metabolism, immune function and reproduction in mammals. The ECS is consisted of the endocannabinoid (eCB) ligands, enzymes, and cannabinoid receptors. In mammals, the cannabinoid-1 receptor (CB1/CNR1) is expressed in the central nervous system and in peripheral tissues; and its activation increases anabolic processes.
View Article and Find Full Text PDFA method of enhanced shear wave elastography based on Chirp coded excitation.
Ultrasonics
January 2025
Medical Ultrasound Department for the Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163, China. Electronic address:
Shear Wave Elastography (SWE) is an imaging technique that detects shear waves generated by tissue excited by Acoustic Radiation Force (ARF), and characterizes the mechanical properties of soft tissue by analyzing the propagation velocity of shear wave. ARF induces a change in energy density through the nonlinear propagation of ultrasound waves, which drives the tissue to generate shear waves. However, the amplitude of shear waves generated by ARF is weak, and the shear waves are strongly attenuated in vivo.
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