Objective: To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes.
Research Design And Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Double-blind RCTs of > or =6 months duration in obese subjects age < or =19 years without diabetes were included. Our primary outcomes of interest include changes in BMI and measures of insulin sensitivity.
Results: Five trials met inclusion criteria (n = 320 individuals). Compared with placebo, metformin reduced BMI by 1.42 kg/m(2) (95% CI 0.83-2.02) and homeostasis model assessment insulin of resistance (HOMA-IR) score by 2.01 (95% CI 0.75-3.26).
Conclusions: Metformin appears to be moderately efficacious in reducing BMI and insulin resistance in hyperinsulinemic obese children and adolescents in the short term. Larger, longer-term studies in different populations are needed to establish its role in the treatment of overweight children.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732169 | PMC |
| http://dx.doi.org/10.2337/dc09-0258 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Mobile App for Promoting Breastfeeding-Friendly Communities in Hong Kong: Design and Development Study.
JMIR Form Res
January 2025
School of Nursing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 5/F, Academic Building, Pokfulam, Hong Kong, China (Hong Kong), 852 39176690.
Background: Breastfeeding is vital for the health and well-being of both mothers and infants, and it is crucial to create supportive environments that promote and maintain breastfeeding practices.
Objective: The objective of this paper was to describe the development of a breastfeeding-friendly app called "bfGPS" (HKU TALIC), which provides comprehensive territory-wide information on breastfeeding facilities in Hong Kong, with the goal of fostering a breastfeeding-friendly community.
Methods: The development of bfGPS can be categorized into three phases, which are (1) planning, prototype development, and preimplementation evaluation; (2) implementation and updates; and (3) usability evaluation.
Unlabelled: It is currently estimated that every 15 minutes an infant is born with opioid use disorder and undergoes intense early life trauma due to opioid withdrawal. Clinical research on the long-term consequences of gestational opioid exposure reports increased rates of social, conduct, and emotional disorders in these children. Here, we investigate the impact of perinatal opioid exposure (POE) on behaviors associated with anhedonia and stress in male and female Sprague Dawley rats.
View Article and Find Full Text PDFEvaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India.
Cureus
December 2024
Internal Medicine, Medanta - The Medicity, Gurgaon, IND.
Background And Objective: Iron deficiency anemia (IDA) is a prominent cause of anemia adversely affecting the physical, mental, and social well-being of an individual. It is a major health concern and has impacted more than two billion people worldwide. It is necessary to implement programs to increase compliance rates for iron and folic acid (IFA) supplementation and educate individuals about anemia.
View Article and Find Full Text PDFA multimodal neural signature of face processing in autism within the fusiform gyrus.
Nat Ment Health
January 2025
Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich, Switzerland.
Atypical face processing is commonly reported in autism. Its neural correlates have been explored extensively across single neuroimaging modalities within key regions of the face processing network, such as the fusiform gyrus (FFG). Nonetheless, it is poorly understood how variation in brain anatomy and function jointly impacts face processing and social functioning.
View Article and Find Full Text PDFInfant action understanding: the roles of active training and motor development.
Front Dev Psychol
May 2024
Infant Learning and Development Laboratory, Department of Psychology, Division of Social Sciences, University of Chicago, Chicago, IL, United States.
Introduction: This study examined the potential interplay between motor development and intervention in support of action understanding.
Methods: Eighty nine-month-old infants completed a tool-use training session and goal imitation paradigm that assessed action understanding in counterbalanced order. A metric of motor development was obtained using the Early Motor Questionnaire.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!