AI Article Synopsis
- - The report details the creation and evaluation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, which were developed by modifying existing cardioactive compounds, LASSBio-294 and LASSBio-785.
- - Researchers assessed the vasodilatory (blood vessel widening) effects of these new compounds and found that some exhibit enhanced vasorelaxant properties compared to their predecessors.
- - The findings suggest that these novel derivatives show promise as potential new candidates for cardiovascular drugs.
Article Abstract
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates.
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| http://dx.doi.org/10.1016/j.ejmech.2009.04.044 | DOI Listing |
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