It is currently reported that extracellular matrix, biological scaffolds, conditions of stress, nutrients and metabolic waste play very important roles in tissue-engineered osteochondral composite. In this paper, we have made a review of their effects on such composite.
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Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration.
Nanomicro Lett
November 2024
Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Article Synopsis
- - The complex structure of musculoskeletal tissues demands advanced scaffold designs for effective tissue engineering, driving interest in gradient bone scaffolds that mimic natural tissue matrices.
- - This review explores various strategies for creating biomimetic gradient scaffolds, emphasizing their compositional and structural gradients for repairing bones, osteochondral issues, and tendon-to-bone interfaces.
- - It also highlights recent animal testing of these scaffolds and discusses the challenges and future potential of applying them in clinical settings for treating musculoskeletal injuries.
Effectiveness and Safety of Matrix-Associated Autologous Chondrocyte Implantation for the Treatment of Articular Cartilage Defects: A Real-World Data Analysis in Japan.
Am J Sports Med
November 2024
Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori Prefecture, Japan.
Article Synopsis
- The study investigates the effectiveness and safety of matrix-associated autologous chondrocyte implantation with an autologous periosteal flap (pMACI) for treating large cartilage defects in the knee.
- Data were analyzed from 232 knees in 225 patients, focusing on outcomes such as the Lysholm knee score and KOOS at different follow-up intervals.
- The findings showed that a significant percentage of patients reported meaningful improvements in knee function and symptoms, with higher success rates in those who did not undergo additional surgeries like microfracture.
Osteochondral tissue engineering in translational practice: histological assessments and scoring systems.
Front Bioeng Biotechnol
August 2024
Orthopedic Medical Center, The Second Hospital of Jilin University, Jilin, China.
Osteochondral lesions are common pathological alterations in synovial joints. Different techniques have been designed to achieve osteochondral repair, and tissue-engineered osteochondral grafts have shown the most promise. Histological assessments and related scoring systems are crucial for evaluating the quality of regenerated tissue, and the interpretation and comparison of various repair techniques require the establishment of a reliable and widely accepted histological method.
View Article and Find Full Text PDFA rabbit osteochondral defect (OCD) model for evaluation of tissue engineered implants on their biosafety and efficacy in osteochondral repair.
Front Bioeng Biotechnol
May 2024
Musculoskeletal Research Laboratory of Department of Orthopaedics and Traumatology and Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Osteochondral defect (OCD) is a common but challenging condition in orthopaedics that imposes huge socioeconomic burdens in our aging society. It is imperative to accelerate the R&D of regenerative scaffolds using osteochondral tissue engineering concepts. Yet, all innovative implant-based treatments require animal testing models to verify their feasibility, biosafety, and efficacy before proceeding to human trials.
View Article and Find Full Text PDFControlled Mechanical Property Gradients Within a Digital Light Processing Printed Hydrogel-Composite Osteochondral Scaffold.
Ann Biomed Eng
August 2024
Paul M. Rady Department of Mechanical Engineering, University of Colorado at Boulder, 427 UCB, Boulder, CO, 80309, USA.
Tissue engineered scaffolds are needed to support physiological loads and emulate the micrometer-scale strain gradients within tissues that guide cell mechanobiological responses. We designed and fabricated micro-truss structures to possess spatially varying geometry and controlled stiffness gradients. Using a custom projection microstereolithography (μSLA) system, using digital light projection (DLP), and photopolymerizable poly(ethylene glycol) diacrylate (PEGDA) hydrogel monomers, three designs with feature sizes < 200 μm were formed: (1) uniform structure with 1 MPa structural modulus ( ) designed to match equilibrium modulus of healthy articular cartilage, (2) = 1 MPa gradient structure designed to vary strain with depth, and (3) osteochondral bilayer with distinct cartilage ( = 1 MPa) and bone ( = 7 MPa) layers.
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