1. The pharmacokinetics and toxicodynamics of single and multiple doses of cyclosporine were studied in the immunized rat model and compared with non-immunized rats. 2. The pharmacokinetics of cyclosporine i.v. (5 mg/kg per day) were similar in immunized and non-immunized rats after single or multiple doses. 3. The absolute bioavailabilities of single and multiple doses of cyclosporine (10 mg/kg per day) given orally were significantly decreased in immunized rats compared with non-immunized rats. 4. Oral administration of cyclosporine (10 mg/kg per day) did not alter renal function of non-immunized rats compared with untreated controls. However, inulin clearance decreased greater than four-fold in immunized rats given cyclosporine for 7 days. 5. In summary, the pharmacokinetics and toxicodynamics of cyclosporine given orally to rats are affected by the immune system.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/00498259109039520 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative evaluation of gold nanoparticles and Alum as immune enhancers against rabies vaccine and related immune reactivity, physiological, and histopathological alterations: study.
Clin Exp Vaccine Res
January 2023
The Holding Company for Production of Vaccines, Sera and Drugs (VACSERA-EgyVac), Giza, Egypt.
Purpose: The present study aimed to compare the immune-enhancing potential of gold nanoparticles (AuNPs) to Alum against rabies vaccine and the related immunological, physiological, and histopathological effects.
Materials And Methods: Alum and AuNPs sole and in combination with rabies vaccine were used at 0.35 mg/mL and 40 nM/mL, respectively.
Pregestational Exposure to Produces Maternal Antibodies That Recognize Fetal Brain Mimotopes and Induces Neurochemical and Behavioral Dysfunction in the Offspring.
Cells
November 2022
Neurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
The activation of the maternal immune system by a prenatal infection is considered a risk factor for developing psychiatric disorders in the offspring. is one of the pathogenic infections associated with schizophrenia. Recent studies have shown an association between high levels of IgG anti- from mothers and their neonates, with a higher risk of developing schizophrenia.
View Article and Find Full Text PDFBeneficial effect of dimethyl fumarate on experimental autoimmune uveitis is dependent of pro-inflammatory markers immunomodulation.
Inflammopharmacology
October 2021
Laboratory of Cellular and Molecular Biology, Team "Cytokines and NO Synthases", Department of Biology, Faculty of Biological Science, University of Sciences and Technology Houari Boumediene, BP 32, El-Alia, 16111, Algiers, Algeria.
Autoimmune uveitis is an inflammatory disease of the eye and is one of the major causes of blindness worldwide. Experimental autoimmune uveoretinitis (EAU) constitutes an animal disease model of human endogenous uveitis. In our study, we investigated the immunomodulatory effect of dimethyl fumarate (DMF) using bovine retinal extract-induced uveitis in a Female Wistar rats.
View Article and Find Full Text PDFRecombinant Measles AIK-C Vaccine Strain Expressing Influenza HA Protein.
Vaccines (Basel)
March 2020
Laboratory of Viral Infection II, Kitasato Institute for Life Sciences, Tokyo 108-8641, Japan.
Recombinant measles AIK-C vaccine expressing the hemagglutinin (HA) protein of influenza A/Sapporo/107/2013(H1N1pdm) (MVAIK/PdmHA) was constructed. Measles particle agglutination (PA) and influenza hemagglutinin inhibition (HI) antibodies were induced in cotton rats immunized with MVAIK/PdmHA. Cotton rats immunized with two doses of the HA split vaccine were used as positive controls, and higher HI antibodies were detected 3 weeks after the first dose.
View Article and Find Full Text PDFA histopathologic study of the controlling role of T cells on experimental periodontitis in rats.
J Dent Sci
June 2018
Department of Periodontology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Background/purpose: The onset and progression of periodontitis involve bacterial infection and the immune response. T cells function in the immune response and reportedly induce bone resorption in inflammatory bone loss. However, the exact role of T cells in periodontal destruction remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!