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Biologically-oriented alveolar ridge preservation to correct bone dehiscence at immediate implant placement.
Clin Adv Periodontics
January 2025
Operative Unit of Dentistry, Azienda Unità Sanitaria Locale, Ferrara, Italy.
Background: The purpose of the present case study is to describe the application of a modification of the Biologically-oriented Alveolar Ridge Preservation (BARP) principles in cases of peri-implant bone dehiscence (PIBD) due to a compromised alveolus at immediate implant placement (IIP).
Methods: The technique is based on the stratification of three layers: a deep layer with a collagen sponge (CS) in the apical part of the alveolus (where the buccal bone plate was still present) to support the blood clot; a graft layer to correct the PIBD; and a superficial collagen layer to cover the graft thus providing space and enhancing clot/graft stability. Healing was obtained by primary closure.
sc-SPLASH provides ultra-efficient reference-free discovery in barcoded single-cell sequencing.
bioRxiv
December 2024
Department of Biomedical Data Science, Stanford University, Stanford, 94305, USA.
Typical high-throughput single-cell RNA-sequencing (scRNA-seq) analyses are primarily conducted by (pseudo)alignment, through the lens of annotated gene models, and aimed at detecting differential gene expression. This misses diversity generated by other mechanisms that diversify the transcriptome such as splicing and V(D)J recombination, and is blind to sequences missing from imperfect reference genomes. Here, we present sc-SPLASH, a highly efficient pipeline that extends our SPLASH framework for statistics-first, reference-free discovery to barcoded scRNA-seq (10x Chromium) and spatial transcriptomics (10x Visium); we also provide its optimized module for preprocessing and -mer counting in barcoded data, BKC, as a standalone tool.
View Article and Find Full Text PDFOne Ring does not rule them all: Linear mtDNA in Metazoa.
Gene
January 2025
Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA, USA. Electronic address:
Article Synopsis
- * This review highlights the presence of linear mitochondrial DNA in various non-bilaterian animals, with specific origins linked to mechanisms like linear plasmids and tRNA heteroplasmy.
- * The authors emphasize the importance of including all available linear mtDNA data, even if classified as "incomplete," as they can still contribute valuable insights into evolutionary relationships and gene organization.
Streptomyces-Fungus Co-Culture Enhances the Production of Borrelidin and Analogs: A Genomic and Metabolomic Approach.
Mar Drugs
June 2024
College of Ocean and Earth Science, Xiamen University, Xiamen 361005, China.
The marine Streptomyces harbor numerous biosynthetic gene clusters (BGCs) with exploitable potential. However, many secondary metabolites cannot be produced under laboratory conditions. Co-culture strategies of marine microorganisms have yielded novel natural products with diverse biological activities.
View Article and Find Full Text PDFEvolution of glial cells: a non-bilaterian perspective.
Neural Dev
June 2024
Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0412, Japan.
Nervous systems of bilaterian animals generally consist of two cell types: neurons and glial cells. Despite accumulating data about the many important functions glial cells serve in bilaterian nervous systems, the evolutionary origin of this abundant cell type remains unclear. Current hypotheses regarding glial evolution are mostly based on data from model bilaterians.
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