Some patterns of connective tissue metabolism were studied in rabbit blood and aorta after local administration of angiotensin II into lateral ventricle of brain and ventromedian nucleus of hypothalamus. Within the first 10 days of the chronic experiments catabolism of connective tissue predominated, while anabolic processes, accompanied by accumulation of collagen in aorta, were elevated within 30 days. The alterations observed were most distinct after microinjection of angiotensin II into hypothalamus. Both modulating effect of angiotensin II on the adrenohypophysial system and the peptide immediate action were apparently responsible for alterations in metabolism of connective tissue-related biopolymers.
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