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Extending Conjugation Lengths of the Linkage Units in Triazine-Based Porous Polymers for Enhanced Photocatalysis.
Small Methods
December 2024
School of Chemical Engineering, The University of Adelaide, North Terrace, Adelaide, SA, 5005, Australia.
Three triazine-based conjugated porous polymers (CPPs) are synthesized via a Pd-catalyzed Suzuki-Miyaura coupling reaction between derivatives of 2,4,6-tri(thiophen-2-yl)-1,3,5-triazine (TTT) and 2,4,6-triphenyl-1,3,5-triazine (TPT). Photocatalysis experiments demonstrate that the hydrogen evolution rate (HER) of ThTh-CPP (homopolymer of TTT) reach an exceptional 46.4 mmol g⁻¹ h⁻¹ without co-catalysts, surpassing ThPh-CPP (8.
View Article and Find Full Text PDFTotal Syntheses of Diepoxy-Kaurane Diterpenoids Enabled by a Bridgehead-Enone-Initiated Intramolecular Cycloaddition.
J Am Chem Soc
December 2024
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Here, we report the enantioselective total syntheses of four diepoxy--kaurane diterpenoids including (-)-Macrocalin B, (-)-Acetyl-macrocalin B, and (-)-Isoadenolin A and the revised structure of (-)-Phyllostacin I, which hinges on the strategic design of a regioselective and stereospecific trapping of a highly reactive [3.2.1]-bridgehead enone intermediate via a tethered intramolecular Diels-Alder reaction.
View Article and Find Full Text PDFA cross-shaped organic framework: a multi-functional template arranging chromophores.
Org Chem Front
December 2024
Department of Chemistry, University of Basel St Johanns-Ring 19 Basel 4056 Switzerland https://www.chemie1.unibas.ch/Bmayor/.
This work explores the use of a cross-shaped organic framework that is used as a template for the investigation of multi-functionalized chromophores. We report the design and synthesis of a universal cross-shaped building block bearing two bromines and two iodines on its peripheral positions. The template can be synthesized on a gram scale in a five-step reaction comprising an oxidative homo-coupling macro-cyclization.
View Article and Find Full Text PDFGeneral access to furan-substituted -difluoroalkenes enabled by PFTB-promoted cross-coupling of ene-yne-ketones and difluorocarbene.
Chem Sci
December 2024
Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University Wuhan 430071 China
Replacement of a carbonyl group with fluorinated bioisostere (, CF[double bond, length as m-dash]C) has been adopted as a key tactical strategy in drug design and development, which typically improves potency and modulates lipophilicity while maintaining biological activity. Consequently, new -difluoroalkenation reactions have undoubtedly accelerated this shift, and conceptually innovative practices would be of great benefit to medicinal chemists. Here we describe an expeditous protocol for the direct assembly of furan-substituted -difluoroalkenes PFTB-promoted cross-coupling of ene-yne-ketones and difluorocarbene.
View Article and Find Full Text PDFOral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs.
Front Reprod Health
December 2024
Bilateral Health Office, United States Agency for International Development, Pretoria, South Africa.
Since the introduction of oral pre-exposure prophylaxis (PrEP) in 2016, countries have successfully scaled-up PrEP to populations at risk of HIV acquisition, including key populations, serodiscordant couples and pregnant women. Between 2016 and 2023, there were over 5.6 million oral PrEP initiations globally.
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