We present a novel method for three-dimensional optical splitter that have U-grooves, which are used for fiber alignment, within a fused silica glass using near-IR femtosecond laser pulses. The fiber aligned optical splitter has a low insertion loss, less than 4 dB, including an intrinsic splitting loss of 3 dB and excess loss due to the passive alignment of a single-mode fiber. The output field pattern is presented, demonstrating the splitting ratio of the optical splitter is approximately 1:1. Finally, we demonstrate the utility of the femtosecond laser writing of periodic patterns by fabricating the submicron line and dot patterns inside the silica glass, which is applicable to 3-D optical memory.
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http://dx.doi.org/10.1364/opex.13.004224 | DOI Listing |
Sci Rep
December 2024
Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, Kyungbook, Republic of Korea.
Alanine racemase (Alr) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent racemization between L- and D-alanine in bacteria. Owing to the potential interest in targeting Alr for antibacterial drug development, several studies have determined the structures of Alr from different species, proposing models for the reaction mechanism. Insights into its reaction dynamics may be conducive to a better understanding of the Alr reaction mechanism.
View Article and Find Full Text PDFBMC Ophthalmol
December 2024
School of Medicine, Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, 361000, China.
Purepose: The intraoperative femtosecond laser time, Cumulative Dissipated Energy (CDE), Effective Phacoemulsification time (EPT), and intraoperative fluid perfusion volume were compared under different model fragmentation modes using Catalys femtosecond laser system.
Methods: This was a single-center, prospective, randomized controlled study. A total of 120 eyes who underwent femtosecond laser-assisted cataract phacoemulsification combined with intraocular lens implantation in Xiamen Eye Center affiliated to Xiamen University from September 2022 to March 2023 were randomly divided into 4 groups to undergo pre-nucleus splitting in different ways: Group 1: six-split, Group 2: eight-split, Group 3: six-split + gridded softening, and Group 4: eight-split + gridded softening.
Biosensors (Basel)
November 2024
Institute of Laser Engineering, Osaka University, Suita 565-0871, Osaka, Japan.
Biosensors operating in the terahertz (THz) region are gaining substantial interest in biomedical analysis due to their significant potential for high-sensitivity trace-amount solution detection. However, progress in compact, high-sensitivity chips and methods for simple, rapid and trace-level measurements is limited by the spatial resolution of THz waves and their strong absorption in polar solvents. In this work, a compact nonlinear optical crystal (NLOC)-based reflective THz biosensor with a few arrays of asymmetrical meta-atoms was developed.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHK-Shenzhen), Shenzhen, Guangdong, 518172, P. R. China.
The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate of glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy and severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by the second near-infrared (NIR-II) light, offers an unprecedented opportunity to address this challenge, attributed to its combinational merits of PDT and TP excitation.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Institute of Materials Science and Engineering, Chemnitz University of Technology, Erfenschlager Straße 73, Chemnitz 09125, Germany.
The generation of laser-induced periodic surface structures (LIPSS) using femtosecond lasers facilitates the engineering of material surfaces with tailored functional properties. Numerous aspects of their complex formation process are still under debate, despite intensive theoretical and experimental research in recent decades. This particularly concerns the challenge of verifying approaches based on electromagnetic effects or hydrodynamic processes by experiment.
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