AI Article Synopsis
- A genotyping study analyzed 285 specimens using a low-risk probe cocktail and found cross-reactivity with various human papillomavirus (HPV) genotypes.
- The cross-reactivity usually helped clinicians by identifying untargeted low-risk HPV types.
- However, 8.4% of positive results were weak and linked to high-risk genotypes, suggesting the need for a "gray zone" in interpretations.
Article Abstract
A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725686 | PMC |
| http://dx.doi.org/10.1128/JCM.00278-09 | DOI Listing |
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