Background: Ectopic breast tissues can be found along the embryonic mammary ridges and can occur in the vulva. While ectopic breast tissue is not uncommon, functional breast with overlying nipple located within the vulva is exceedingly rare.
Case: A 17-year-old with undiagnosed hypothyroidism presents with vulvar mass draining milky white fluid. A small lesion with appearance similar to a skin tag is noted and milky fluid expressed. Biopsy and excision of this mass confirmed the presence of a functional supernumerary nipple.
Summary And Conclusions: This appears to be the first reported case of a supernumerary nipple with symptomatic lactation in a non-pregnant adolescent. Supernumerary nipple should be considered in the differential diagnosis of a vulvar mass. Ectopic breast tissue in the vulva can undergo malignant transformation, therefore excision of this tissue is generally recommended.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpag.2008.03.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
EHMT2 as a Candidate Gene for an Autosomal Recessive Neurodevelopmental Syndrome.
Mol Neurobiol
December 2024
Department of Genetics and Evolutionary Biology, Institute of Biosciences, Human Genome and Stem Cell Research Center, University of Sao Paulo (USP), Sao Paulo, SP, Brazil.
Neurodevelopmental disorders (NDD) comprise clinical conditions with high genetic heterogeneity and a notable enrichment of genes involved in regulating chromatin structure and function. The EHMT1/2 epigenetic complex plays a crucial role in repression of gene transcription in a highly tissue- and temporal-specific manner. Mutations resulting in heterozygous loss-of-function (LoF) of EHMT1 are implicated in Kleefstra syndrome 1 (KS1).
View Article and Find Full Text PDFIdentification of Goat Supernumerary Teat Phenotype Using Wide-Genomic Copy Number Variants.
Animals (Basel)
November 2024
College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Supernumerary teats (SNTs) or nipples often emerge around the mammary line. This study performed a genome-wide selective sweep analysis (GWS) at the copy number variant (CNV) level using two selected signal calculation methods ( and ) to identify candidate genes associated with SNTs in goats. A total of 12,310 CNVs were identified from 37 animals and 123 CNVs, with the top 1% values including 84 candidate genes (CDGs).
View Article and Find Full Text PDF[Polythelia: About A Case And Litterature Review].
Mali Med
November 2024
Gynécologie CHU Gabriel Touré.
Polythelia also known as supernumerary is an anomaly in the breast development by extra number of nipples. We report a case of polythelia in the Gynecology-Obstetrics department of the CHU Gabriel Touré. This was a 32-year-old woman received for pregnancy monitoring, in whom we accidentally discovered three pairs of nipples located on both breasts.
View Article and Find Full Text PDFWhole Genome Sequencing Solves an Atypical Form of Bardet-Biedl Syndrome: Identification of Novel Pathogenic Variants of .
Int J Mol Sci
July 2024
Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, 00161 Rome, Italy.
Article Synopsis
- Bardet-Biedl syndrome (BBS) is a rare genetic disorder with symptoms like vision loss, obesity, extra fingers or toes, cognitive issues, and genitourinary defects, caused by mutations in various genes.
- An 18-year-old boy showing symptoms of BBS underwent genetic testing, but initial methods didn't provide a clear diagnosis until whole-genome sequencing revealed two significant genetic changes affecting the BBS9 protein.
- The study emphasizes the importance of whole-genome sequencing for diagnosing rare diseases and highlights the need for functional validation to better understand the impact of genetic variants.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!