Completely implantable ports have become increasingly popular for venous access in the treatment of cancer. An uncommon but very serious complication is reported here: extravasation of a cytostatic agent secondary to a damaged Port-a-Cath catheter. Guidelines to be observed in implantation are recommended.
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CHEMOTHERAPY HAZARDS: ANTHRACYCLINE EXTRAVASATION INTO PLEURAL SPACE.
Port J Card Thorac Vasc Surg
April 2022
Chest Department, Centro Hospitalar Universitário Lisboa Norte - Hospital Pulido Valente, Portugal.
The extravasation of doxorubicin, a cytostatic from the anthracycline group, is a rare and feared complication of intravenous chemotherapy due to tissue toxicity of these drugs. We describe a case of a 64-year-old woman with breast cancer undergoing adjuvant chemotherapy with doxorubicin and cyclophosphamide using a tunneled central catheter. After a chemotherapy cycle, the patient developed cough, dyspnoea and chest pain, due to a pleural effusion secondary to cytostatic leakage.
View Article and Find Full Text PDFUsing Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report.
Iran J Parasitol
January 2021
Institute of Health Sciences, College of Medical Sciences, University of Rzeszów, Rzeszów, Poland.
Extravasation of doxorubicin, vincristine or vinblastine leads to necrosis, damage of the muscles and nerves, deep ulceration, as well as limb dysfunction. Necrosis and deep ulcers develop within 7 to 28 days. Like necrotomy, maggot therapy is recognised as a method enabling effective, safe and quick removal of necrotic tissue.
View Article and Find Full Text PDFExtending the Applicability of and Chicken Chorioallantoic Membrane Assays to Study Cytostatic Activity in Neuroblastoma Cells.
Front Oncol
September 2021
Research Group for Molecular Biology and Nanomedicine, Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czechia.
Purpose: The chick chorioallantoic membrane (CAM) assay can provide an alternative versatile, cost-effective, and ethically less controversial model for reliable screening of drugs. In the presented work, we demonstrate that CAM assay ( and ) can be simply employed to delineate the effects of cisplatin (CDDP) and ellipticine (Elli) on neuroblastoma (Nbl) cells in terms of their growth and metastatic potential.
Methods: The Nbl UKF-NB-4 cell line was established from recurrent bone marrow metastases of high-risk Nbl (stage IV, amplification, 7q21 gain).
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View Article and Find Full Text PDFBackground: Extravasation (paravasation) of chemotherapy drugs is a very significant complication in the treatment of cancer patients. Preventive and therapeutic interventions reduce the risk of this complication or the extent of its consequences. A working group of authors from expert groups prepared recommendations for standard care.
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