Rickettsia akari is the causative agent of rickettsialpox, a primarily urban mite-borne rickettsiosis that is encountered in the United States and in a few countries around the world. Its vector is the mite Liponyssoides sanguineus, which is found on rats and mice, which serve as reservoirs for the disease. In this work we report a severe animal case of R. akari infection with two unusual features: R. akari was found in a dog, and its potential vector was a tick.
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Structural determination of lipid A without chemical extraction confirms shorter acyl chains in later-evolving spotted fever group pathogens.
mSphere
February 2024
Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Article Synopsis
- Rickettsiae are Gram-negative parasites that primarily infect blood-feeding arthropods and include human pathogens from transitional, typhus, and spotted fever groups, each with distinct clinical manifestations and genetic characteristics.
- Unlike many organisms, rickettsiae lack glycolysis and rely on stealing metabolites from their host to produce essential components like peptidoglycan and lipopolysaccharide (LPS).
- Recent research using an advanced lipid analysis technique called FLAT has revealed differences in the lipid A structures of spotted fever group rickettsiae, suggesting a divergence in secondary acyl chain lengths that may influence their inflammatory potential and interactions with host receptors.
Unlabelled: Rickettsiae are Gram-negative obligate intracellular parasites of numerous eukaryotes. Human pathogens of the Transitional Group (TRG), Typhus Group (TG), and Spotted Fever Group (SFG) rickettsiae infect blood-feeding arthropods, have dissimilar clinical manifestations, and possess unique genomic and morphological attributes. Lacking glycolysis, rickettsiae pilfer numerous metabolites from host cytosol to synthesize peptidoglycan and lipopolysaccharide (LPS).
View Article and Find Full Text PDFDeregulates Genes Coding for the Neurotoxic Cell Response Pathways in Cerebrocortical Neurons In Vitro.
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Department of Rickettsiology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia.
Rickettsial infections of the central nervous system (CNS) are manifested by severe neurological symptoms and represent a serious life-threatening condition. Despite the considerable health danger, only a few studies have been conducted focusing on the pathogenesis induced by sp. in CNS.
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Department of Entomology, Texas A&M University, College Station, Texas, USA.
Spotted fever group species are intracellular bacteria transmitted by tick or mite vectors and that cause human diseases referred to as spotted fever group rickettsioses, or spotted fevers. In the United States, the most recognized and commonly reported spotted fevers are Rocky Mountain spotted fever (RMSF) (), rickettsiosis, Pacific Coast tick fever ( species 364D), and rickettsialpox (). In this study, we summarize and evaluate surveillance data on spotted fever cases reported to the Centers for Disease Control and Prevention (CDC) through the National Notifiable Diseases Surveillance System from 2010 to 2018.
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