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Pregnancy and Long-Term Postnatal Outcomes of Congenital Sacrococcygeal Teratoma: A Single Institution's 18-Year Experience.
Birth Defects Res
October 2024
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
Objective: The objective of this study is to evaluate outcomes of fetal sacrococcygeal teratoma (SCT) from an academic tertiary center.
Study Design: This is a retrospective study evaluating pregnancy and postnatal outcomes of fetal SCT management at a single institution between 2006 and 2023. Results are reported as median (range).
Nasal immature teratoma in an elderly patient: Clinicopathological and epigenetic analogies with central nervous system counterparts, alongside genomic divergences.
Neuropathology
October 2024
Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Germ cell tumors (GCTs) are categorized as gonadal or extra-gonadal, based on the origin. Extra-gonadal GCTs predominantly manifest within the central nervous system (CNS), mediastinum, retroperitoneum, and sacrococcygeal region. These malignancies are most frequently diagnosed in the pediatric, adolescent, and young adult demographics.
View Article and Find Full Text PDFA fetus with a mass in the oral cavity: A rare case of large oral immature teratoma.
SAGE Open Med Case Rep
September 2024
Department of Pathology, Aga Khan University Hospital, Karachi, Pakistan.
Oral teratoma is a congenital neoplastic lesion with an incidence of 2%-9% of all teratomas. It comprises variable amounts of all three germ cell layers. The lesion is graded on histology depending upon the presence of immature components.
View Article and Find Full Text PDFMalignant transformation and tumour recurrence in sacrococcygeal teratoma: a global, retrospective cohort study.
Int J Surg
November 2024
Department of Paediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam.
Article Synopsis
- Sacrococcygeal teratoma (SCT) is a rare congenital tumor with unclear risks of malignancy and recurrence, prompting a study to better understand these factors.
- A global retrospective cohort study analyzed data from 3,612 SCT patients across 145 institutes in 62 countries, focusing on malignant transformation and recurrence rates.
- Results showed that the risk of malignancy increases with age, plateauing at six years, while 10.2% of patients experienced recurrence, with significant associations related to tumor type and initial histology.
The Diagnostic Accuracy of Serum Alpha-Fetoprotein Levels in Follow-up for Recurrence of Sacrococcygeal Teratoma; a Nationwide Review of SCT Cases in the Netherlands.
J Pediatr Surg
September 2024
Emma Children's Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, Department of Pediatric Surgery, Amsterdam, the Netherlands.
Background: Serum alpha-fetoprotein (AFP) is often used as tumour marker for recurrent sacrococcygeal teratoma (SCT). We aimed to assess the normal dynamics of serum AFP levels after initial resection and diagnostic accuracy of serum AFP levels the follow-up for recurrence in SCT.
Methods: This retrospective study included 57 patients treated for SCT in the six pediatric surgical centers in the Netherlands from 1980 to 2018.
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