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Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model.
APMIS
January 2025
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)-derived halogenated furanones, which act to block the QS pathway, against key fungal pathogens of the skin (Candida albicans, Malassezia furfur and Microsporum gypseum). Moreover, we aimed to assess how these actives performed against complex interkingdom biofilms in a clinically relevant model.
View Article and Find Full Text PDFFemoral Component Malrotation Following Total Knee Arthroplasty in the Presence of Hypoplasia: Is the Orthopedic Surgeon Aware?
Cureus
December 2024
Orthopaedics and Traumatology, Kocaeli State Hospital, Kocaeli, TUR.
Background This study hypothesizes that patients with femoral condylar hypoplasia who undergo total knee arthroplasty (TKA) may experience femoral component malrotation and that the surgeon performing the operation may not notice it. The aim is to measure the rotational alignment of the femoral components and assess the functional outcomes in these patients. Materials and methods Between December 2018 and December 2022, a total of 96 knees from 80 patients were evaluated.
View Article and Find Full Text PDFFluid Management in Critical Care: New Insights Into Optimal Fluid Therapy.
Cureus
December 2024
Critical Care Medicine, Star Care Multispeciality Hospital, Kozhikode, IND.
Background: Fluid management is a crucial critical care component, influencing outcomes such as organ function, renal integrity, and survival in critically ill patients. Recent evidence suggests that balanced crystalloids may offer advantages over isotonic saline, particularly in reducing the risk of acute kidney injury (AKI) and other complications. This study aimed to evaluate the impact of balanced crystalloids versus isotonic saline on clinical outcomes in the intensive care unit (ICU), focusing on AKI, renal replacement therapy (RRT), and mortality.
View Article and Find Full Text PDFEvaluation of the Accuracy of Digital Models Generated Using Photogrammetry.
Cureus
December 2024
Department of Prosthetic Dental Sciences, College of Dentistry, Jouf University, Sakaka, SAU.
Introduction: In contemporary clinical settings, three-dimensional (3D) models have become an integral component of daily practice. Photogrammetry, a novel method in clinical practice, enables the creation of precise 3D models from small objects while maintaining their original shape and size.
Aim: To evaluate the accuracy and reliability of digital models (DM) generated using photogrammetry techniques compared to traditional gypsum models (GM) and to investigate the feasibility of utilizing free software for processing and manipulating digital dental models.
Assessment of Malocclusion and Gender Differences in Orthodontic Treatment Needs Among Adolescents Aged 10-13 Years in Eastern India: A Cross-Sectional Study.
Cureus
December 2024
Department of Orthodontics and Dentofacial Orthopedics, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, IND.
Introduction: Malocclusion is a prevalent public health concern among adolescents, impacting both dental health and psychosocial well-being.
Aims And Objectives: To assess the prevalence of orthodontic treatment needs among adolescents aged 10-13 years in Bhubaneswar using the dental health component (DHC) and aesthetic component (AC) of the Index of Orthodontic Treatment Need (IOTN) and to analyze gender-based differences.
Methodology: A cross-sectional study was conducted among 450 school-going children aged 10-13 years using cluster sampling across Bhubaneswar.
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