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Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis.
Front Immunol
January 2025
Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, United States.
The placenta is a unique organ with various immunological and endocrinological roles that modulate maternal and fetal physiology to promote maternal-fetal tolerance, pregnancy maintenance, and parturition at term. During pregnancy, the hormone prolactin (PRL) is constitutively secreted by the placenta and is necessary for implantation, progesterone support, fetal development, and overall immune modulation. While PRL is essential for pregnancy, studies suggest that elevated levels of serum PRL (hyperprolactinemia) are associated with adverse pregnancy outcomes, including miscarriage, preterm birth, and preeclampsia.
View Article and Find Full Text PDFExperience and trust: the benefits of mate familiarity are realized through sex-specific specialization of parental roles in Cassin's auklet.
R Soc Open Sci
December 2024
Department of Animal Science, University of California, Davis, CA, USA.
Maintaining a pair bond year after year (perennial monogamy) often enhances reproductive success, but what familiar pairs are doing differently to improve success is unknown. We tested the hypothesis that endocrine changes mediate improvements in parental attendance in known-age Cassin's auklets , for which we found limited evidence. Instead, we found sex-specific parental roles in familiar pairs.
View Article and Find Full Text PDFPrognostic significance of CNNM4 in ovarian cancer: a comprehensive bioinformatics analysis.
Front Oncol
December 2024
School of Life Sciences, Qilu Normal University, Jinan, China.
Background: Ovarian cancer (OV) is a common malignancy in the female reproductive system, characterized by poor prognosis and high recurrence rates. The discovery of dependable molecular markers is crucial for improving the timeliness of detection, diagnosis, and treatment, ultimately aiming to lower fatality rates. CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4), a member of the CNNM (Cyclin M) family, binds to PRL (prolactin) to regulate magnesium homeostasis and influence tumor cell proliferation.
View Article and Find Full Text PDFExploring the anti-cancer properties of as a multi-targeted approach against breast cancer.
J Biomol Struct Dyn
December 2024
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
The escalating incidence of breast cancer globally presents a formidable challenge within oncology. Our research pursued an examination of the anti-cancer potential of , a shrub traditionally used for medicinal purposes and known for its composition of vital nutrients and phytochemicals. We employed a network pharmacology strategy combined with molecular docking and molecular dynamics simulations to elucidate the intricate relationships between the phytochemical constituents of , critical breast cancer proteins, and associated signaling pathways.
View Article and Find Full Text PDFEffect of Thyroid Status Modulation on Pituitary and Peripheral Hormone Concentrations in Healthy Older Subjects.
Neuroendocrinology
December 2024
Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Introduction: Depending on age, sex, and familial longevity, alterations in thyroid status occur frequently and often co-occur with differences in other hormonal axes. However, studies that explore the effects of thyroid status modulation on other hormonal axes remain scarce. We aimed to determine the effects of thyroid status modulation on prolactin, IGF-1, cortisol, LH, testosterone, and SHBG levels.
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