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Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report.
Beyoglu Eye J
February 2019
Department of Ophthalmology, Darica Farabi Training and Research Hospital, Kocaeli, Turkey.
Topiramate is primarily used as an antiepileptic drug. It has also demonstrated effectiveness in migraine prophylaxis, depression, trigeminal neuralgia, bipolar disorders, and idiopathic intracranial hypertension. The drug has a large number of potential ocular side effects, such as acute-onset angle closure glaucoma (ACG), acute myopia, nystagmus, diplopia, photosensitivity, suprachoroidal effusions, peri-orbital edema, and blepharospasm.
View Article and Find Full Text PDFTopiramate-induced acute onset myopia: a case report.
BMC Res Notes
September 2014
Teaching hospital, Peradeniya, Sri Lanka.
Background: Topiramate is a drug which emerged from its anticonvulsant properties and now over the years is used for a wider range of indications, including migraine prophylaxis. We described a very rare case of topiramate induced acute onset myopia during use for migraine. It is the first reported case of its kind from Sri Lanka with only a handful of reported cases in world literature.
View Article and Find Full Text PDFAcute myopia and angle closure glaucoma from topiramate in a seven-year-old: a case report and review of the literature.
BMC Pediatr
April 2014
Vanderbilt Eye Institute, 2311 Pierce Avenue, Nashville, TN 37232, USA.
Background: A case is reported of acute bilateral myopia and angle closure glaucoma in a 7-year-old patient from topiramate toxicity. This is the second known reported case of topiramate induced acute angle closure glaucoma and third known reported case of topiramate induced acute myopia in a pediatric patient.
Case Presentation: This case presents a 7-year-old who had recently begun topiramate therapy for seizures and headache.
Timing and clinical characteristics of topiramate-induced psychosis in a patient with epilepsy and tuberous sclerosis.
Clin Neuropharmacol
September 2014
Department of Neuroscience, Unit of Child Neurology and Psychiatry, "Tor Vergata" University of Rome, Rome, Italy.
Several lines of scientific evidence showed that topiramate may induce psychotic symptoms when used as monotherapy. It has been postulated that this topiramate effect may be caused by the inhibition of frontal and prefrontal areas induced by topiramate. The clinical history of the patient described shows that topiramate may also induce psychosis when used in polytherapy.
View Article and Find Full Text PDFTopiramate-induced confusion following a single ingestion of 400 mg.
Gen Hosp Psychiatry
April 2011
Duke University Hospital, Durham, NC 27710, USA.
Background: Topiramate is an anticonvulsant medication commonly used for a variety of neurological disorders including migraine prophylaxis. Broadened use of topiramate has brought an increased awareness of toxicity from this medication, particularly central nervous system side effects and metabolic acidosis.
Objective: We describe a case of topiramate toxicity occurring in a 22-year-old female following the ingestion of two 200 mg tablets, which she was prescribed for the treatment of migraines.
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