To study the content of protein S-100 and tumor-necrosis factor-alpha (TNF-alpha) in the serum of patients with discirculatory encephalopathy (DE), stages I and II, 108 patients have been examined. The diagnosis of vascular damage of the brain has been confirmed by ultrasound and MRI-examination. Patients with DE, stage II, had significantly higher levels of protein S-100 and TNF-alpha (0.764+/-0.021 optical density units (ODU) and 0.797+/-0.039 pg/l, respectively) compared to the control group (0.540+/-0.015 ODU and 0.528+/-0.001 pg/l; p<0.001). Lesser differences were found between patients with stage II and stage I. The levels of protein S-100 and TNF-alpha increased with age and illness duration (p<0.05). The data obtained can be used in diagnostics of chronic cerebral blood circulation disorders and prognosis of disease outcome.
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