The treatment of oral and dental diseases during the war is complicated with many aggravating circumstances, such as: a great number of ill and injured persons per dental team; limited handling of all kinds of material, lack of time, etc. The paper deals with the epidemiological research of the most frequent oral diseases in soldiers of the Yugoslav Army. The need for dental care was established upon these data. Since the discrepancy between the requests and possibilities is obvious, it is emphasized that the rationalization of treatment of oral and dental diseases can give favourable results even in war conditions.
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Eur J Med Chem
January 2025
Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Healthand, Department of Frontiers Science Center for Disease-related Molecular Network, Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:
NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.
View Article and Find Full Text PDFJ Clin Psychiatry
January 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York.
To provide proof-of-concept (PoC), dose-range finding, and safety data for BI 1358894, a TRPC4/5 ion channel inhibitor, in patients with borderline personality disorder (BPD). This was a phase 2, multinational, randomized, double-blind, placebo controlled trial. Patients were randomized to oral placebo or BI 1358894 (5 mg, 25 mg, 75 mg, or 125 mg) once daily in a 2.
View Article and Find Full Text PDFDentomaxillofac Radiol
January 2025
Division of Oral Radiology, Faculdade São Leopoldo Mandic.
Objectives: The aim of this technical report was to assess whether the "Radiological Report" tool within the Artificial Intelligence (AI) software Diagnocat can achieve a satisfactory level of performance comparable to that of experienced dentomaxillofacial radiologists in interpreting cone-beam CT scans.
Methods: Ten cone-beam CT scans were carefully selected and analyzed using the AI tool, and they were also evaluated by two dentomaxillofacial radiologists. Observations related to tooth numeration, alterations in dental crowns, roots, and periodontal tissues were documented and subsequently compared to the AI findings.
Europace
December 2024
Research Group Cardiovascular Diseases, University of Antwerp, Prinsstraat 13, Antwerp 2000, Belgium.
Aims: Trials on integrated care for atrial fibrillation (AF) showed mixed results in different AF populations using various approaches. The multicentre, randomized AF-EduCare trial evaluated the effect of targeted patient education on unplanned cardiovascular outcomes.
Methods And Results: Patients willing to participate were randomly assigned to in-person education, online education, or standard care (SC) and followed for minimum 18 months.
JMIR Res Protoc
January 2025
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Background: Telehomecare monitoring (TM) in patients with cancer is a complex intervention. Research shows variations in the benefits and challenges TM brings to equitable access to care, the therapeutic relationship, self-management, and practice transformation. Further investigation into these variations factors will improve implementation processes and produce effective outcomes.
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