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Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep.
J Anim Sci Biotechnol
December 2024
Key Laboratory of Adaptation and Evolution of Plateau Biota, Qinghai Provincial Key Laboratory of Animal Ecological Genomics, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, 810008, China.
Introduction: Tibetan sheep, economically important animals on the Qinghai-Tibet Plateau, have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective breeding. However, most current research focuses on one or two breeds, and lacks a comprehensive representation of the genetic diversity across multiple Tibetan sheep breeds. This study aims to fill this gap by investigating the genetic structure, diversity and high-altitude adaptation of 6 Tibetan sheep breeds using whole-genome resequencing data.
View Article and Find Full Text PDFIdentification of the Emerging C1-like Lineage of Enterovirus A71 in Two Uruguayan Children with Hand-Foot-and-Mouth Disease and Neurological Complications.
Viruses
November 2024
Molecular Virology Lab, Department of Biological Sciences, Centro Universitario Regional Litoral Norte, Universidad de la República, Salto 50000, Salto, Uruguay.
Enterovirus A71 (EV-A71) is a major cause of hand-foot-and-mouth disease (HFMD), particularly in cases that involve complications affecting the nervous system or cardiopulmonary function. In South America, EV-A71 has primarily been identified through studies of acute flaccid paralysis (AFP) and other neurological disorders. In September 2022, two children from a small city in Uruguay were hospitalized with presumptive rhombencephalitis, exhibiting symptoms of HFMD.
View Article and Find Full Text PDFHigh-parametric protein maps reveal the spatial organization in early-developing human lung.
Nat Commun
October 2024
Science for Life Laboratory, Solna, Sweden.
Article Synopsis
- The study focuses on the lung's development during the first trimester of human pregnancy, emphasizing its importance for life on land.
- It utilizes advanced imaging and analysis techniques to map the protein-level organization of lung cells over various stages of gestation, examining more than 2 million cells.
- The findings offer a detailed resource on the types of cells in the developing lung as well as their growth and spatial patterns, serving as a foundation for future research on respiratory health.
A multimodal characterization of cardiopulmonary resuscitation-associated lung edema.
Intensive Care Med Exp
October 2024
Department of Pathophysiology and Transplants, University of Milan, Milan, Italy.
Article Synopsis
- CRALE (Cardiopulmonary resuscitation-associated lung edema) is a condition observed in patients who undergo cardiac arrest and CPR, influencing both respiratory and cardiovascular systems.
- An experimental model of cardiac arrest was used to study CRALE, with manual and mechanical chest compressions compared, showing significant respiratory complications due to decreased lung compliance and poor oxygen delivery.
- Results indicated that after 25 minutes of CPR, animals exhibited signs of CRALE such as increased lung weight and reduced aeration, suggesting a correlation between CPR mechanics and lung edema severity.
Withdrawal/Withholding of Life-Sustaining Therapies: Limitation of Therapeutic Effort in the Intensive Care Unit.
Medicina (Kaunas)
September 2024
Department of Anesthesiology, Intensive Care and Pain Medicine, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
: The change in critically ill patients makes limitation of therapeutic effort (LTE) a widespread practice when therapeutic goals cannot be achieved. We aimed to describe the application of LTE in a post-surgical Intensive Care Unit (ICU), analyze the measures used, the characteristics of the patients, and their evolution. Retrospective observational study, including all patients to whom LTE was applied in a postsurgical ICU between January 2021 and December 2022.
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