Disorders of sex development (DSD), previously termed intersex, are uncommon, and are usually, but not always, diagnosed at birth. Issues of gender assignment, psychosexual development and the potential for malignant change in a dysgenetic gonad need to be considered. Here, we report a rare presentation of advanced malignancy in an abdominal gonad associated with the formation of a uterus in an adult male with a previously undiagnosed DSD.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.5694/j.1326-5377.2009.tb02595.x | DOI Listing |
Pathologica
October 2024
Pathology Unit, Department of Oncology, ASST Sette Laghi, Varese, Italy.
P53-abnormal endometrial carcinomas are high-grade and aggressive tumors which should be treated with chemo-/radiotherapy. In low-grade endometrioid carcinoma (LGEC), abnormal expression of p53 is an exceptional finding and is typically accompanied by patchy p16 positivity and diffuse hormone receptor expression. Herein, we report a case of LGEC exhibiting both p53 and p16 overexpression, highlighting the diagnostic pitfalls related to such phenotype.
View Article and Find Full Text PDFReproduction
December 2024
V Chennathukuzhi, Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, United States.
Placenta
December 2024
Department of Obstetrics and Gynecology and Reproductive Medicine, Peking University First Hospital, Beijing, China; Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, China. Electronic address:
J Am Geriatr Soc
November 2024
Department of Anesthesia & Perioperative Care, University of California, San Francisco, California, USA.
Background: Older adults often require surgical care and are at elevated risk of delirium. We explored delirium risk profiles across the population of U.S.
View Article and Find Full Text PDFVirchows Arch
October 2024
Bioptical Laboratory, Ltd., Pilsen, Czech Republic.
NTRK-rearranged spindle cell neoplasm represents an emerging entity included in the latest 5th edition of WHO classification of both soft tissue and female genital tumors. By immunohistochemistry, they are commonly positive for CD34, S100 protein, and CD30 and typically harbor fusions of kinase genes such as NTRK1/2/3, RET, and BRAF. In the gynecological tract, they typically affect the uterine cervix or uterine body.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!