AI Article Synopsis
- The bark of maritime pine is noted for its use in treating degenerative diseases and contains beneficial compounds such as caffeic acid, catechin, ferulic acid, and taxifolin.
- A high-performance liquid chromatography (HPLC) method, as per the United States Pharmacopeia, was employed to analyze Pycnogenol in dietary supplements for quality and composition.
- Analysis of twelve dietary supplement samples revealed that two did not match the standard Pycnogenol extract, indicating possible additional ingredients or quality control problems during production.
Article Abstract
The bark of maritime pine (Pinus pinaster Aiton) has been widely used as a remedy for various degenerative diseases. A standard high-performance liquid chromatographic (HPLC) procedure for Pycnogenol analysis is a method specified in the United States Pharmacopeia (USP) monograph, which requires measurement of peak areas and identification of four components of the extract: caffeic acid, catechin, ferulic acid, and taxifolin. In this study, a fingerprint analysis using an HPLC method based on the USP monograph has been developed to provide additional qualitative information for the analysis of Pycnogenol-containing dietary supplements (PDS). Twelve commercially available PDS samples were purchased and analyzed along with a standard Pycnogenol extract. Their chromatographic fingerprints were analyzed using principal component analysis. The results showed that two of the samples were not consistent with the standard reference Pycnogenol extract. One contained other active ingredients in addition to Pycnogenol, and the other may have resulted from a quality control issue in manufacturing.
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