AI Article Synopsis
- The cells in the central nervous system (CNS) actively participate in immune responses, with microglia, astrocytes, and neurons expressing various innate immune receptors like toll-like receptors (TLRs).
- TLRs can identify common structural patterns in pathogens, indicating they're involved in both infectious and non-infectious diseases affecting the CNS.
- Research is ongoing to develop therapies that target TLR activity to treat conditions related to infections and inflammation in the brain.
Article Abstract
Far from being an immune-inert site, the cells of the CNS, including microglia, astrocytes and neurons, express an abundance of innate immune receptors, including toll like receptors (TLR), which recognize conserved structural motifs in pathogens. These TLRs have been implicated in both infectious and non-infectious CNS pathology and appear to play important roles in both tissue surveying and repair. Therapeutics that modulate their activity are being explored for the treatment of infectious and inflammatory diseases.
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| http://dx.doi.org/10.2741/e43 | DOI Listing |
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