AI Article Synopsis
- TWEAK is a cytokine that activates the Fn14 receptor and is involved in various biological processes like cell growth, death, and inflammation.
- Its expression increases during injury to blood vessels and kidneys, and it can lead to cell death under inflammatory conditions.
- Research indicates TWEAK plays a significant role in kidney and vascular inflammation, suggesting it could be a potential target for new treatments in related injuries.
Article Abstract
TWEAK is a cytokine of the TNF superfamily that activates the Fn14 receptor. TWEAK may regulate cell proliferation, cell death, cell differentiation, angiogenesis and inflammation. The expression of TWEAK and Fn14 is increased during vascular and renal injury. Inflammatory cytokines increase Fn14 receptor expression in tubular and vascular smooth muscle cells. Moreover, TWEAK induces tubular cell apoptosis under proinflammatory conditions. TWEAK itself contributes to renal and vascular inflammation by promoting chemokine and inflammatory cytokine secretion. Confirmation of its role in acute kidney injury and atherosclerotic lesions formation came from functional studies in experimental animal models. The available evidence suggests that TWEAK might be a target for therapeutic intervention in renal and vascular injury and its role in different forms of tissue damage should be further explored.
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| http://dx.doi.org/10.1016/j.cytogfr.2009.05.002 | DOI Listing |
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