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Hematological Changes in Clozapine Users: A Study in a Brazilian Community Sample.
Trends Psychiatry Psychother
December 2024
Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia, Escola Paulista de Medicina, Universidade Federal de São Paulo (PROESQ-EPM/UNIFESP), São Paulo, SP, Brazil.
Introduction: Clozapine is the only antipsychotic with proven superior efficacy for treatment-resistant schizophrenia. However, global utilization rates remain suboptimal due to concerns about hematological side effects. This study aimed to investigate hematological abnormalities among clozapine users at a large community center in the Brazilian countryside.
View Article and Find Full Text PDFEfficacy and safety of low-dose rituximab in the treatment of myasthenia gravis: a systemic review and meta-analysis.
Front Neurol
September 2024
Department of Neurology, Changzhi People's Hospital, Changzhi, China.
Article Synopsis
- Rituximab (RTX) is a monoclonal antibody increasingly used to treat myasthenia gravis (MG), with studies investigating the effectiveness of low doses, although its benefits continue to be debated.* -
- A systematic review and meta-analysis of 17 studies with 292 patients showed that 91% experienced improved clinical status after RTX treatment, and their Quantitative Myasthenia Gravis (QMG) scores significantly decreased.* -
- In subgroups, 90% of patients with acetylcholine receptor antibody-positive MG and 97% of those with muscle-specific kinase antibody-positive MG reported clinical improvements, highlighting RTX's potential efficacy in treating different MG types.*
Eosinophil-associated diseases: the Allergist's and Clinical Immunologist's perspective.
Eur Ann Allergy Clin Immunol
September 2024
Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Italy.
Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), less common primary eosinophilic disorders of gastrointestinal tract, and rare conditions including eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). A literature search was carried out in January 2024 in the MEDLINE and Scopus databases using the PubMed search engine (PubMed, National Library of Medicine, Bethesda, MD).
View Article and Find Full Text PDFA delayed diagnosis of fascioliasis: The importance of appropriate fecal diagnostic method.
J Infect Chemother
May 2024
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Fascioliasis, a zoonotic helminthiasis, occurs sporadically in Japan. In this report, we describe a case of fascioliasis that was initially difficult to diagnose because the fecal examination method was negative for the Fasciola sp. eggs.
View Article and Find Full Text PDFBringing the treatable traits approach to primary care asthma management.
Front Allergy
September 2023
Wolfson Institute of Population Health and Asthma UK Centre for Applied Research, Queen Mary University of London, London, United Kingdom.
Asthma continues to be a major cause of illness with a significant mortality, despite its increasing range of treatments. Adoption of a treatable traits approach in specialist centres has led to improvements in control of asthma and reduced exacerbations in patients with severe asthma. However, most patients with this illness, particularly those with mild-to-moderate asthma, are cared for in primary care according to guidelines that emphasise the use of pharmacotherapeutic ladders uniformly implemented across all patients.
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