AI Article Synopsis
- The study focuses on the impact of ligating the left renal vein (LRV) and associated collateral veins in rats that have had one kidney removed (right-nephrectomized).
- The research compares outcomes of ligating the LRV alone and with the adrenal or gonadal collaterals, revealing that excluding gonadal collateral leads to significantly higher mortality due to kidney damage.
- The conclusion highlights that ligation of the LRV near the inferior vena cava is safer when the gonadal collateral is preserved, while ligating it with adrenal collateral is less harmful.
Article Abstract
Background: In cases of trauma to the left renal vein (LRV), its ligation near the inferior vena cava (IVC) is considered, but the consequences are not always good. We investigated the role of collateral venous drainage after ligation of the LRV by studying the renal function and histology after ligation of the LRV near the IVC alone or with ligation of the gonadal or adrenal collaterals, in right-nephrectomized (RN) rats.
Material And Methods: Ligation of the LRV near the IVC alone (group 1) or with ligation of the adrenal (group 2) or gonadal (group 3) collaterals was studied in RN Wistar rats (n=18 per group). The renal histopathology (ischemic cortical necrosis) and functional status (urea, creatinine, sodium, and potassium) were compared.
Results: In RN rats, the results were better when ligating the LRV near the IVC alone or with the adrenal collaterals [mortality 4/18 (22.2%) and 3/18 (16.7%), respectively] than when ligating the LRV near the IVC plus the gonadal collaterals [mortality 15/18 (83.3%)] (p<0.0001). All early deaths occurred within three days and resulted from serious histopathological (ischemic cortical necrosis) and functional (increased urea, creatinine, and potassium; decreased sodium) renal damage.
Conclusion: In right-nephrectomized rats, the LRV near the IVC and the adrenal collateral can be ligated, while the gonadal collateral should be preserved.
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| http://dx.doi.org/10.1016/j.ijsu.2009.05.006 | DOI Listing |
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