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Four-Week Outcomes of Transforaminal Epidural Injections in Patients With Lumbar Radicular Pain.
Cureus
December 2024
Orthopedic Surgery, King Edward Medical University, Lahore, PAK.
Background Lumbar radicular pain occurs due to irritation or compression of the nerve roots in the lower back. This study aimed to evaluate the efficacy of transforaminal epidural steroid injections (TFESIs) in reducing pain and improving functional outcomes in a diverse patient population with lumbar radicular pain. Methodology This quasi-experimental trial was performed at the Department of Orthopedic Surgery and Traumatology, Unit 1, Mayo Hospital, Lahore, from October 2021 to September 2022.
View Article and Find Full Text PDFInfluence of Intraoperative Pain Management on Postoperative Delirium in Elderly Patients: A Prospective Single-Center Randomized Controlled Trial.
Pain Ther
February 2025
Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Introduction: Intraoperative analgesia and sedation are closely related to postoperative delirium. Depth of sedation based on bispectral index (BIS) guidance has been shown to reduce the occurrence of postoperative delirium (POD). However, the correlation between intraoperative analgesia levels and POD is unclear.
View Article and Find Full Text PDFNanotechnology in Pain Management.
Pharmaceutics
November 2024
Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA.
Article Synopsis
- Chronic pain affects millions globally, leading to significant loss in wages and increasing healthcare costs due to dependency on traditional pain medications with serious side effects.
- Common medications like opioids and NSAIDs can result in harmful complications and serious risks such as addiction and overdose, prompting a critical need for alternative treatments.
- Nanotechnology offers promising solutions for chronic pain relief by creating advanced drug delivery systems that enhance efficacy while minimizing side effects, with innovative methods including nanocapacitor patches and gene therapy being explored.
Sodium channels Na1.7, Na1.8 and pain; two distinct mechanisms for Na1.7 null analgesia.
Neurobiol Pain
October 2024
Molecular Nociception Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London WC1E 6BT, UK.
Genetic deletion and pharmacological inhibition are distinct approaches to unravelling pain mechanisms, identifying targets and developing new analgesics. Both approaches have been applied to the voltage-gated sodium channels Na1.7 and Na1.
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