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SarkoLife: quality of life in patients undergoing multimodal soft tissue sarcoma treatment.
World J Surg Oncol
January 2025
Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Trauma Center Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, Tuebingen, 72076, Germany.
Objective: To assess the tolerability of multimodal therapy in soft tissue sarcoma patients, particularly with regard to their quality of life and level of distress.
Materials And Methods: A retrospective cohort study enrolled individuals receiving sarcoma therapy at the sarcoma center of the University of Tuebingen between 2017 and 2022. Participants completed an online survey that included the EORTC's questionnaire (QLQ-C30), coupled with the distress thermometer and demographic inquiries.
Very severe aortic valve stenosis: Diagnostic value of computed tomography aortic valve calcium scoring.
J Cardiovasc Comput Tomogr
December 2024
Department of Internal Medicine II, Division of Cardiology, Austria.
Background: (A) Very severe aortic valve stenosis (VSAS; Vmax ≥ 5 m/s, MPG ≥60 mmHg) is a critical condition with unfavorable clinical outcomes. Guidelines regard VSAS as one criterion for considering valve replacement in asymptomatic patients. (B) Guidelines recommend the use of aortic valve calcium (AVC) scoring as a parameter to differentiate between moderate and severe aortic valve stenosis (SAS).
View Article and Find Full Text PDFPersistent sodium currents in neurons: potential mechanisms and pharmacological blockers.
Pflugers Arch
October 2024
Institute for Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany.
Article Synopsis
- Persistent sodium current (I) plays a crucial role in regulating neuronal excitability and is linked to several neurological conditions, but its underlying mechanisms and pharmacological tools are not well understood.
- Researchers conducted a systematic review to clarify existing knowledge and highlight the differences in definitions and methodologies used in studying I.
- They identified various sodium current blockers with differing pharmacological effects, concluding that GS967 and riluzole are effective I blockers, while phenytoin and lacosamide target only specific components of the sodium current.
Deciphering the Role of microRNAs: Unveiling Clinical Biomarkers and Therapeutic Avenues in Atrial Fibrillation and Associated Stroke-A Systematic Review.
Int J Mol Sci
May 2024
Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by binding to target messenger RNAs (mRNAs). miRNAs have been implicated in a variety of cardiovascular and neurological diseases, such as myocardial infarction, cardiomyopathies of various geneses, rhythmological diseases, neurodegenerative illnesses and strokes. Numerous studies have focused on the expression of miRNA patterns with respect to atrial fibrillation (AF) or acute ischemic stroke (AIS) However, only a few studies have addressed the expression pattern of miRNAs in patients with AF and AIS in order to provide not only preventive information but also to identify therapeutic potentials.
View Article and Find Full Text PDFStandardization of a CT Protocol for Imaging Patients with Suspected COVID-19-A RACOON Project.
Bioengineering (Basel)
February 2024
Department of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
CT protocols that diagnose COVID-19 vary in regard to the associated radiation exposure and the desired image quality (IQ). This study aims to evaluate CT protocols of hospitals participating in the RACOON (Radiological Cooperative Network) project, consolidating CT protocols to provide recommendations and strategies for future pandemics. In this retrospective study, CT acquisitions of COVID-19 patients scanned between March 2020 and October 2020 (RACOON phase 1) were included, and all non-contrast protocols were evaluated.
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