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Comprehensive evaluation of lifespan-extending molecules in C. elegans.
Aging Cell
January 2025
EPITERNA, Epalinges, Switzerland.
The nematode C. elegans has long served as a gold-standard model organism in aging research, particularly since the discovery of long-lived mutants in conserved aging pathways including daf-2 (IGF1) and age-1 (PI3K). Its short lifespan and small size make it highly suitable for high-throughput experiments.
View Article and Find Full Text PDFThe Esthetic Use of Botulinum Toxins in Cancer Patients: Providing a Foundation for Future Indications.
Toxins (Basel)
January 2025
Executive Committee of Agorà-Italian Society of Aesthetic Medicine, 20122 Milan, Italy.
Advances in oncological treatments have improved the survival rates of cancer patients but have often resulted in significant physical changes that negatively impact their self-esteem and psychological well-being. Cancer patients frequently ask esthetic practitioners to perform procedures to address such changes. However, practitioners often hesitate to satisfy such requests due to lacking guidelines or recommendations.
View Article and Find Full Text PDFPrimary Epithelioid Angiosarcoma of the Penis: A Case Report With a Brief Review of the Literature.
Am J Dermatopathol
February 2025
Clinic of Dermatology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Angiosarcoma of the penis is an exceptionally rare mesenchymal tumor, with only about 30 cases documented in the literature. Because of its rarity and the often nonspecific clinical presentation, histopathological examination plays a critical role in accurate diagnosis. Angiosarcoma of the penis typically arises in the corpus cavernosum but has also been reported in the glans and urethra, often presenting with metastases.
View Article and Find Full Text PDFYaws in Africa: Past, Present and Future.
Diseases
January 2025
Department of Medical Microbiology, University of Ghana Medical School, Accra P.O. Box GP 4236, Ghana.
Yaws is an infectious, neglected tropical disease that affects the skin of many children and adolescents who live in poor, rural, low-income communities in humid, tropical areas of Africa, Southeast Asia, and the Pacific Islands. Yaws is currently endemic in at least 15 countries, but adequate surveillance data are lacking. In line with the WHO's effort to improve early detection, diagnosis, and proper management leading to the eventual eradication of yaws, this article reviews the existing literature on yaws in Africa to highlight the epidemiological pattern, genetic variability, diagnosis modalities, treatment, and control strategies, the challenges and prospects for yaws eradication.
View Article and Find Full Text PDFRelationship Between Sedentary Lifestyle, Physical Activity and Stress in University Students and Their Life Habits: A Scoping Review with PRISMA Checklist (PRISMA-ScR).
Brain Sci
January 2025
Department of Psychology and Education, Pegaso Telematic University, 80143 Naples, Italy.
Unlabelled: The global prevalence of sedentary lifestyles and the associated health risks, such as cardiovascular, metabolic and mental issues, is an epidemic worldwide problem, particularly in the university population.
Background/objectives: University students are particularly vulnerable because of academic pressure and lifestyle changes. Despite the well-known benefits of physical activity in reducing mental stress and improving physical and mental well-being, the literature lacks effective interventions and standardized protocols for this population.
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